Phenotypes associated with this allele

• Allele Symbol: Adam3^tm1Ihgg
• Allele Name: targeted mutation 1, Institut fur Humangenetik
• Allele ID: MGI:2156166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adam3^tm1Ihgg/Adam3^tm1Ihgg	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:2665287

Genotype
MGI:2665287

hm1

• Allelic Composition: Adam3^tm1Ihgg/Adam3^tm1Ihgg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:58730 )

N • in homozygous mutant mice, sperm motility and sperm transport through the female reproductive tract appeared normal

N • no significant differences were observed in assays of the sperm acrosome reaction between mutant and wild-type sperm

male infertility ( J:58730 )

♂ • all homozygous mutant male mice were infertile, despite normal sexual behavior and production of copulation plugs

impaired binding of sperm to zona pellucida ( J:58730 )

♂ • in vitro fertilization experiments revealed that mutant sperm failed to bind to the zona pellucida

♂ • however, zona-free eggs fertilized by mutant sperm developed normally to 2- and 4-cell stages