Mouse Genome Informatics
hm1
    Psen1tm1Jzt/Psen1tm1Jzt
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
normal phenotype
• homozygous mice are indistinguishable from wild-type mice


Mouse Genome Informatics
cn2
    Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests

cellular
• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls

nervous system
• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:73252


Mouse Genome Informatics
cn3
    Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• by 10 months of age mutants have impaired performance in a novel object recognition test
• by 10 months of age some mutants show increased activity in an open field test

cellular
• a dramatic increase in apoptosis is seen in the degenerating forebrain

growth/size
• by 10 months of age mutant mice start to show reduced body weights compared to wild-type

nervous system
• the lateral ventricles are immensely enlarged compared to wild-type or single knockout mice
• the third ventricle is immensely enlarged compared to wild-type or single knockout mice
• the thickness of the corpus callosum is about a third that of controls
• the thickness of the molecular layers between the CA1 pyramidal cells and dentate gyrus is significantly reduced
• the cortex is about half the normal thickness and the 6 layers can no longer be distinguished
• increased Gfap expression indicates that reactive astrogliosis occurs along with forebrain degeneration
• changes in the expression of several markers indicate that neuronal atrophy occurs along with forebrain degeneration
• degeneration is seen in the forebrain

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 4 606889 J:90685
Alzheimer Disease; AD 104300 J:90685