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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Jzt
targeted mutation 1, Joe Z Tsien
MGI:2155978
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1Jzt/Psen1tm1Jzt involves: C57BL/6 * CBA MGI:3045189
cn2
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA MGI:3045183
cn3
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
involves: C57BL/6 * CBA MGI:3045186


Genotype
MGI:3045189
hm1
Allelic
Composition
Psen1tm1Jzt/Psen1tm1Jzt
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• homozygous mice are indistinguishable from wild-type mice




Genotype
MGI:3045183
cn2
Allelic
Composition
Psen1tm1Jzt/Psen1tm1Jzt
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (28 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exposure to environmental enrichment following contextual fear conditioning results in a significant increase in freezing responses during retention tests

cellular
• environmental enrichment induces significantly less neurogenesis in the dentate gyrus of the brain in mutants compared to wild-type controls

nervous system
• following environmental enrichment the number of newborn neurons in the subgranular zone and molecular layer of the dentate gyrus are 39% and 48% less respectively compared to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:73252




Genotype
MGI:3045186
cn3
Allelic
Composition
Psen1tm1Jzt/Psen1tm1Jzt
Psen2tm1Ber/Psen2tm1Ber
Tg(Camk2a-cre)T29-1Stl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Jzt mutation (0 available); any Psen1 mutation (28 available)
Psen2tm1Ber mutation (0 available); any Psen2 mutation (16 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• by 10 months of age mutants have impaired performance in a novel object recognition test
• by 10 months of age some mutants show increased activity in an open field test

cellular
• a dramatic increase in apoptosis is seen in the degenerating forebrain

growth/size/body
• by 10 months of age mutant mice start to show reduced body weights compared to wild-type

nervous system
• the lateral ventricles are immensely enlarged compared to wild-type or single knockout mice
• the third ventricle is immensely enlarged compared to wild-type or single knockout mice
• the thickness of the corpus callosum is about a third that of controls
• the thickness of the molecular layers between the CA1 pyramidal cells and dentate gyrus is significantly reduced
• the cortex is about half the normal thickness and the 6 layers can no longer be distinguished
• increased Gfap expression indicates that reactive astrogliosis occurs along with forebrain degeneration
• changes in the expression of several markers indicate that neuronal atrophy occurs along with forebrain degeneration
• degeneration is seen in the forebrain

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 4 606889 J:90685
Alzheimer Disease; AD 104300 J:90685





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory