All Phenotypes Sle2<NZM2410/Aeg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sle2^NZM2410/Aeg
NZM2410/Aeg
MGI:2155957

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sle2^NZM2410/Aeg/Sle2^NZM2410/Aeg	involves: C57BL/6J * NZM2410/Aeg	MGI:2175458
cx2	Sle1^NZM2410/Aeg/Sle1^NZM2410/Aeg Sle3^NZM2410/Aeg/Sle3^NZM2410/Aeg	B6;NZM-Sle1^NZM2410/Aeg Sle2^NZM2410/Aeg Sle3^NZM2410/Aeg/LmoJ	MGI:3839653

Allelic Composition	Sle2^NZM2410/Aeg/Sle2^NZM2410/Aeg
Genetic Background	involves: C57BL/6J * NZM2410/Aeg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle2^NZM2410/Aeg mutation (1 available); any Sle2 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

glomerulonephritis ( J:25006 )

• susceptibility to glomerulonephritis

renal/urinary system

glomerulonephritis ( J:25006 )

• susceptibility to glomerulonephritis

Allelic Composition	Sle1^NZM2410/Aeg/Sle1^NZM2410/Aeg Sle3^NZM2410/Aeg/Sle3^NZM2410/Aeg
Genetic Background	B6;NZM-Sle1^NZM2410/Aeg Sle2^NZM2410/Aeg Sle3^NZM2410/Aeg/LmoJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sle1^NZM2410/Aeg mutation (2 available); any Sle1 mutation (2 available)
Sle2^NZM2410/Aeg mutation (1 available); any Sle2 mutation (1 available)
Sle3^NZM2410/Aeg mutation (1 available); any Sle3 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased marginal zone B cell number ( J:138314 )

• increased proportion of B220+ CD1d^hi splenic B cells

abnormal marginal zone B cell physiology ( J:138314 )

• impaired TI-2 antigen binding capacity

• increased intrafollicular localization of IgM+ CD1d^hi B cells