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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acetm2Keb
targeted mutation 2, Kenneth E Bernstein
MGI:2155953
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Acetm2Keb/Acetm2Keb involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3720674
ht2
Acetm2Keb/Ace+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3720675


Genotype
MGI:3720674
hm1
Allelic
Composition
Acetm2Keb/Acetm2Keb
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm2Keb mutation (0 available); any Ace mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• males sire smaller litters than wild-type
• however, females produce normal sized litters
• males sire fewer litters than wild-type (3 litters from 14 plugged females compared to 10 litters from 14 plugged females bred to wild-type males)

renal/urinary system
• mice exhibit vascular hypertrophy of the arteries and arterioles
• urine concentration is half that seen in wild-type mice
• half the mice exhibit focal expansion of Bowman's space
• one mouse had unilateral calyceal dilation and three had calyceal dilation similar to that seen in other ACE-deficient mice
• mice produce twice the volume of urine at half the concentration relative to wild-type mice

homeostasis/metabolism
• urine concentration is half that seen in wild-type mice

cardiovascular system
• mice exhibit vascular hypertrophy of the arteries and arterioles
• 75 mmHg compared to 110 mmHg in wild-type mice




Genotype
MGI:3720675
ht2
Allelic
Composition
Acetm2Keb/Ace+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm2Keb mutation (0 available); any Ace mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 95 mmHg compared to 110 mmHg in wild-type mice





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory