Mouse Genome Informatics
hm1
    Acetm2Keb/Acetm2Keb
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• males sire smaller litters than wild-type
• however, females produce normal sized litters
• males sire fewer litters than wild-type (3 litters from 14 plugged females compared to 10 litters from 14 plugged females bred to wild-type males) (J:40475)

renal/urinary system
• mice exhibit vascular hypertrophy of the arteries and arterioles
• urine concentration is half that seen in wild-type mice
• half the mice exhibit focal expansion of Bowman's space
• one mouse had unilateral calyceal dilation and three had calyceal dilation similar to that seen in other ACE-deficient mice
• mice produce twice the volume of urine at half the concentration relative to wild-type mice

homeostasis/metabolism
• urine concentration is half that seen in wild-type mice

cardiovascular system
• mice exhibit vascular hypertrophy of the arteries and arterioles
• 75 mmHg compared to 110 mmHg in wild-type mice


Mouse Genome Informatics
ht2
    Acetm2Keb/Ace+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• 95 mmHg compared to 110 mmHg in wild-type mice