Analysis Tools
reproductive system
|
• males sire smaller litters than wild-type
• however, females produce normal sized litters
|
 |
• males sire fewer litters than wild-type (3 litters from 14 plugged females compared to 10 litters from 14 plugged females bred to wild-type males)
|
renal/urinary system
|
• mice exhibit vascular hypertrophy of the arteries and arterioles
|
|
• urine concentration is half that seen in wild-type mice
|
|
• half the mice exhibit focal expansion of Bowman's space
|
|
• one mouse had unilateral calyceal dilation and three had calyceal dilation similar to that seen in other ACE-deficient mice
|
|
• mice produce twice the volume of urine at half the concentration relative to wild-type mice
|
homeostasis/metabolism
|
• urine concentration is half that seen in wild-type mice
|
cardiovascular system
|
• mice exhibit vascular hypertrophy of the arteries and arterioles
|
|
• 75 mmHg compared to 110 mmHg in wild-type mice
|
