Phenotypes associated with this allele
Allelic
Composition |
Acetm3Unc/Acetm3Unc
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
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cardiovascular system
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• mice exhibit a lower heart weight than in wild-type mice but is not different from heart weights in heterozygous mice
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• mice exhibit a lower heart rate than in wild-type and heterozygous mice
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renal/urinary system
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• cortical width is decreased compared to wild-type and heterogyzous mice
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• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to wild-type and heterogyzous mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
homeostasis/metabolism
cardiovascular system
|
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• in streptozotocin-induced diabetic mice
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renal/urinary system
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• in streptozotocin-induced diabetic, urinary albumin is nearly doubled compared to similarly treated wild-type mice and continues to increase with age
• however, mice fail to exhibit evidence of structural renal injury
|
Allelic
Composition |
Acetm3Unc/Ace+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation
(1 available);
any
Ace mutation
(54 available)
|
|
|
growth/size/body
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• based on weight normalized by food consumption, mice are thinner than wild-type mice
• when fed a high fat diet for 27 weeks, mice weigh less than wild-type mice and Acetm1Unc heterozygotes
• decreased weight when fed a high fat diet cannot be reversed with treatment with losartan (an angiotensin AT1 antagonist)
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renal/urinary system
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• cortical width is decreased compared to wild-type
|
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• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to in wild-type mice
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cardiovascular system
adipose tissue
|
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• when fed a high fat diet, peri-epididymal adipose tissue is reduced
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behavior/neurological
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• food consumption is increased on a normal diet in order to maintain a normal body weight
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endocrine/exocrine glands
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• compared to in Acetm1Unc heterozygotes when fed a high fat diet
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homeostasis/metabolism
Analysis Tools