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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Acetm3Unc
targeted mutation 3, University of North Carolina
MGI:2155951
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Acetm3Unc/Acetm3Unc involves: 129P2/OlaHsd * C57BL/6J MGI:3799525
ht2
Acetm3Unc/Ace+ B6.129P2-Acetm3Unc MGI:3799530
ht3
Acetm3Unc/Ace+ involves: 129P2/OlaHsd * C57BL/6J MGI:3799524


Genotype
MGI:3799525
hm1
Allelic
Composition
Acetm3Unc/Acetm3Unc
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation (1 available); any Ace mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit a lower heart weight than in wild-type mice but is not different from heart weights in heterozygous mice
• mice exhibit a lower heart rate than in wild-type and heterozygous mice

renal/urinary system
• cortical width is decreased compared to wild-type and heterogyzous mice
• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to wild-type and heterogyzous mice




Genotype
MGI:3799530
ht2
Allelic
Composition
Acetm3Unc/Ace+
Genetic
Background
B6.129P2-Acetm3Unc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation (1 available); any Ace mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in streptozotocin-induced diabetic, urinary albumin is nearly doubled compared to similarly treated wild-type mice and continues to increase with age
• however, mice fail to exhibit evidence of structural renal injury

cardiovascular system
• in streptozotocin-induced diabetic mice

renal/urinary system
• in streptozotocin-induced diabetic, urinary albumin is nearly doubled compared to similarly treated wild-type mice and continues to increase with age
• however, mice fail to exhibit evidence of structural renal injury




Genotype
MGI:3799524
ht3
Allelic
Composition
Acetm3Unc/Ace+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acetm3Unc mutation (1 available); any Ace mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• based on weight normalized by food consumption, mice are thinner than wild-type mice
• when fed a high fat diet for 27 weeks, mice weigh less than wild-type mice and Acetm1Unc heterozygotes
• decreased weight when fed a high fat diet cannot be reversed with treatment with losartan (an angiotensin AT1 antagonist)

renal/urinary system
• cortical width is decreased compared to wild-type
• mice exhibit decreased tubulointerstitial tissue per glomerulus compared to in wild-type mice

cardiovascular system

adipose tissue
• when fed a high fat diet, peri-epididymal adipose tissue is reduced

behavior/neurological
• food consumption is increased on a normal diet in order to maintain a normal body weight

endocrine/exocrine glands
• compared to in Acetm1Unc heterozygotes when fed a high fat diet

homeostasis/metabolism
• compared to in Acetm1Unc heterozygotes when fed a high fat diet





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2022
MGI 6.20
The Jackson Laboratory