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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc1tm1Bor
targeted mutation 1, Piet Borst
MGI:2155908
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc1tm1Bor/Abcc1tm1Bor involves: 129P2/OlaHsd * FVB MGI:3619004
cx2
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr MGI:5301410
cx3
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr MGI:5301407


Genotype
MGI:3619004
hm1
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• homozygotes are viable, fertile and healthy under normal conditions, and display no differences in platelet activating factor (PAF)-induced lethality relative to wild-type mice (50% lethality at 200 g/kg)
• at 11-13 weeks, male homozygotes are hypersensitive to etoposide (but not vincristine) toxicity, as shown by increased mortality relative to wild-type mice

homeostasis/metabolism
• at 11-13 weeks, male homozygotes are hypersensitive to etoposide (but not vincristine) toxicity, as shown by increased mortality relative to wild-type mice
• at 11-13 weeks, male homozygotes are hypersensitive to etoposide (but not vincristine) toxicity, as shown by increased body weight loss relative to wild-type mice

immune system
• in vitro, bone marrow-derived mast cells (BMMCs) from mutant mice excrete significantly less LTC4 and accumulate more LTC4 intracellularly relative to wild-type BMMCs; no differences are noted in LTB4 excretion
• homozygotes show a significantly reduced inflammatory response to topical application arachidonic acid, as shown by reduced ear edema and decreased vascular permeability and extravasation of serum proteins relative to wild-type mice
• in contrast, homozygotes exhibit a normal inflammatory response to intradermal injection of LTC4 or topical application of phorbol ester (TPA)

hematopoietic system
• in vitro, bone marrow-derived mast cells (BMMCs) from mutant mice excrete significantly less LTC4 and accumulate more LTC4 intracellularly relative to wild-type BMMCs; no differences are noted in LTB4 excretion




Genotype
MGI:5301410
cx2
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-AppDutch)#Jckr/0
Genetic
Background
FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (34 available)
Tg(Thy1-AppDutch)#Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

homeostasis/metabolism
• number and severity of amyloid beta-immunoreactive vessels is increased compared to single Tg(Thy1-AppDutch)#Jckr mice indicating the development of more severe cerebral amyloid angiopathy
• amyloid beta deposits are increased in neurons of the neocortex and hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Cerebral Amyloid Angiopathy, App-Related 605714 J:178230




Genotype
MGI:5301407
cx3
Allelic
Composition
Abcc1tm1Bor/Abcc1tm1Bor
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/0
Genetic
Background
FVB.Cg-Abcc1tm1Bor Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc1tm1Bor mutation (0 available); any Abcc1 mutation (34 available)
Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increase in microgliosis
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

hematopoietic system
• increase in microgliosis

immune system
• increase in microgliosis

homeostasis/metabolism
• mutants exhibit an increase in the cortical load and size of cerebral amyloid beta-positive plaques compared to single Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:178230





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory