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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pex5tm1Baes
targeted mutation 1, Myriam Baes
MGI:2154454
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pex5tm1Baes/Pex5tm1Baes involves: 129S1/Sv * 129X1/SvJ MGI:2668630


Genotype
MGI:2668630
hm1
Allelic
Composition
Pex5tm1Baes/Pex5tm1Baes
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pex5tm1Baes mutation (0 available); any Pex5 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survival is limited to 3 to 4 days

digestive/alimentary system
• examined at E18.5 and P0

embryo
• as examined at E13.5

growth/size/body
• as examined at E13.5
• 30% body weight reduction at birth compared to littermates

liver/biliary system
• abnormal mitochondrial structure, autophagic vacuoles, accumulation of lipids and increased number of macrophages; absence of peroxisomes in hepatocytes

muscle
• hypotonic, unable to support their weight

renal/urinary system
• autophagic vacuoles, and increased number of macrophages; absence of peroxisomes in renal epithelial cells
• examined at E18.5 and P0

respiratory system
• noted in some neonates, variable onset and severity

nervous system
• reduced thickness of the neocortical plate examined at P0.5
• reduced thickness of cortex

Mouse Models of Human Disease
OMIM ID Ref(s)
Peroxisome Biogenesis Disorder 2A (zellweger); PBD2A 214110 J:42719





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory