Mouse Genome Informatics
hm1
    Pex5tm1Baes/Pex5tm1Baes
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• survival is limited to 3 to 4 days

digestive/alimentary system
• examined at E18.5 and P0

embryogenesis
• as examined at E13.5

growth/size
• as examined at E13.5
• 30% body weight reduction at birth compared to littermates

liver/biliary system
• abnormal mitochondrial structure, autophagic vacuoles, accumulation of lipids and increased number of macrophages; absence of peroxisomes in hepatocytes

muscle
• hypotonic, unable to support their weight

renal/urinary system
• autophagic vacuoles, and increased number of macrophages; absence of peroxisomes in renal epithelial cells
• examined at E18.5 and P0

respiratory system
• noted in some neonates, variable onset and severity

nervous system
• reduced thickness of the neocortical plate examined at P0.5
• reduced thickness of cortex

Mouse Models of Human Disease
OMIM IDRef(s)
Peroxisome Biogenesis Disorder 2A (zellweger); PBD2A 214110 J:42719