Mouse Genome Informatics
hm1
    Ppp3catm1Jse/Ppp3catm1Jse
either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice
• when stimulated with ovalbumin, mice produce less interferon-gamma than wild-type mice
• when stimulated with ovalbumin, mice produce less IL-2 than wild-type mice
• however, primary antibody response is normal in response to TNP-ovalbumin
• when stimulated with ovalbumin, mice produce less IL-4 than wild-type mice

hematopoietic system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:39103


Mouse Genome Informatics
hm2
    Ppp3catm1Jse/Ppp3catm1Jse
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice die between 3 and 4 weeks of age

homeostasis/metabolism
• 1.7+/-0.2 mg per dl compared to 0.5+/-0.1 mg per dl in wild-type mice
• 7+/-1 mg per dl urine creatinine compared to 23+/-2 mg per dl in wild-type mice
• 104+/-34 mg per dl compared to 25+/-2 mg per dl in wild-type mice
• 60+/-35 mg per dl compared to 181+/-17 mg pr dl in wild-type mice
• 9.4+/-0.4 mg per dl compared to 11.0+/-0.5 mg per dl in wild-type mice
• 1400 mOsm per kg compared to 2200mOsm per kg in wild-type mice
• mice fail to increase their urine concentration to the same extent as wild-type mice in response to 1-desamino-8D-arginine vasopressin

renal/urinary system
• 7+/-1 mg per dl urine creatinine compared to 23+/-2 mg per dl in wild-type mice
• 1400 mOsm per kg compared to 2200mOsm per kg in wild-type mice
• mice fail to increase their urine concentration to the same extent as wild-type mice in response to 1-desamino-8D-arginine vasopressin

growth/size
• 5.3+/-0.2 g compared to 10.7+/-0.3 g for wild-type mice (J:110350)
• mice exhibit reduced body weight despite normal muscle weights for their size (25.7+/-1.6 g compared to 30.3+/-0.7 g in wild-type mice) (J:110822)

muscle
• the cross-sectional area of the soleus is increased
• however, the cross-sectional area in the extensor digitorum longus is normal
• the number of fibers in the soleus is decreased
• however, fiber number in the extensor digitorum longus is normal
• the gastrocnemius, biceps and triceps exhibit less oxidative/slow fiber muscle type than wild-type
• however, the oxidative/slow fiber type ratio in the soleus is normal


Mouse Genome Informatics
hm3
    Ppp3catm1Jse/Ppp3catm1Jse
involves: 129S4/SvJae * Black Swiss
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mossy fibers exhibit decreased neurofilament-rich regions compared to wild-type mice
• mossy fibers exhibit abnormal cytoskeletal structures and decreased neurofilament to microtubule ratios compared to wild-type mice


Mouse Genome Informatics
ht4
    Ppp3catm1Jse/Ppp3ca+
involves: 129S4/SvJae
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• mice exhibit a slight delay in reaching maximum postnatal urine concentration compared to wild-type mice

homeostasis/metabolism
• mice exhibit a slight delay in reaching maximum postnatal urine concentration compared to wild-type mice