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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ppp3catm1Jse
targeted mutation 1, Jonathan G Seidman
MGI:2150749
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ppp3catm1Jse/Ppp3catm1Jse either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6) MGI:2174908
hm2
Ppp3catm1Jse/Ppp3catm1Jse involves: 129S4/SvJae MGI:3771568
hm3
Ppp3catm1Jse/Ppp3catm1Jse involves: 129S4/SvJae * Black Swiss MGI:3769692
ht4
Ppp3catm1Jse/Ppp3ca+ involves: 129S4/SvJae MGI:3771570


Genotype
MGI:2174908
hm1
Allelic
Composition
Ppp3catm1Jse/Ppp3catm1Jse
Genetic
Background
either: (involves: 129S4/SvJae * Black Swiss) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3catm1Jse mutation (1 available); any Ppp3ca mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice
• when stimulated with ovalbumin, mice produce less interferon-gamma than wild-type mice
• when stimulated with ovalbumin, mice produce less IL-2 than wild-type mice
• however, primary antibody response is normal in response to TNP-ovalbumin
• when stimulated with ovalbumin, mice produce less IL-4 than wild-type mice

hematopoietic system
• T cell proliferation in response to ovalbumin stimulation is lower than for wild-type mice and is not complimented by normal antibody producing cells or IL-2
• T cells proliferation is more sensitive to cyclosporine A and FK506 exhibiting a 2- to 7-fold lower decreased in proliferation compared to wild-type mice




Genotype
MGI:3771568
hm2
Allelic
Composition
Ppp3catm1Jse/Ppp3catm1Jse
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3catm1Jse mutation (1 available); any Ppp3ca mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between 3 and 4 weeks of age

homeostasis/metabolism
• 1.7+/-0.2 mg per dl compared to 0.5+/-0.1 mg per dl in wild-type mice
• 7+/-1 mg per dl urine creatinine compared to 23+/-2 mg per dl in wild-type mice
• 104+/-34 mg per dl compared to 25+/-2 mg per dl in wild-type mice
• 60+/-35 mg per dl compared to 181+/-17 mg pr dl in wild-type mice
• 9.4+/-0.4 mg per dl compared to 11.0+/-0.5 mg per dl in wild-type mice
• 1400 mOsm per kg compared to 2200mOsm per kg in wild-type mice
• mice fail to increase their urine concentration to the same extent as wild-type mice in response to 1-desamino-8D-arginine vasopressin

renal/urinary system
• 7+/-1 mg per dl urine creatinine compared to 23+/-2 mg per dl in wild-type mice
• 1400 mOsm per kg compared to 2200mOsm per kg in wild-type mice
• mice fail to increase their urine concentration to the same extent as wild-type mice in response to 1-desamino-8D-arginine vasopressin

growth/size/body
• 5.3+/-0.2 g compared to 10.7+/-0.3 g for wild-type mice (J:110350)
• mice exhibit reduced body weight despite normal muscle weights for their size (25.7+/-1.6 g compared to 30.3+/-0.7 g in wild-type mice) (J:110822)

muscle
• the cross-sectional area of the soleus is increased
• however, the cross-sectional area in the extensor digitorum longus is normal
• the number of fibers in the soleus is decreased
• however, fiber number in the extensor digitorum longus is normal
• the gastrocnemius, biceps and triceps exhibit less oxidative/slow fiber muscle type than wild-type
• however, the oxidative/slow fiber type ratio in the soleus is normal




Genotype
MGI:3769692
hm3
Allelic
Composition
Ppp3catm1Jse/Ppp3catm1Jse
Genetic
Background
involves: 129S4/SvJae * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3catm1Jse mutation (1 available); any Ppp3ca mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mossy fibers exhibit decreased neurofilament-rich regions compared to wild-type mice
• mossy fibers exhibit abnormal cytoskeletal structures and decreased neurofilament to microtubule ratios compared to wild-type mice




Genotype
MGI:3771570
ht4
Allelic
Composition
Ppp3catm1Jse/Ppp3ca+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3catm1Jse mutation (1 available); any Ppp3ca mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit a slight delay in reaching maximum postnatal urine concentration compared to wild-type mice

homeostasis/metabolism
• mice exhibit a slight delay in reaching maximum postnatal urine concentration compared to wild-type mice





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory