Phenotypes associated with this allele

• Allele Symbol: Tnc^tm1Sia
• Allele Name: targeted mutation 1, Shinichi Aizawa
• Allele ID: MGI:2148540
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnc^tm1Sia/Tnc^tm1Sia	involves: BALB/c * C57BL/6 * CBA	MGI:2174672
hm2	Tnc^tm1Sia/Tnc^tm1Sia	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5524053
hm3	Tnc^tm1Sia/Tnc^tm1Sia	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:3700279

Genotype
MGI:2174672

hm1

• Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:36890 )

• no histological or anatomical defects were detected in any tissue

• no changes in the distribution of extracellular matrix proteins such as fibronectin, laminin, collagen or proteoglycans

Genotype
MGI:5524053

hm2

• Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:53565 )

N • homozygotes can hear on a gross level, as shown by a Preyer reflex, and display normal cochlear anatomy as well as open fluid spaces in the adult organ of Corti

N • at P3, preliminary studies of neurofilaments indicate that afferent innervation is present in the cochlear outer hair cell region

Genotype
MGI:3700279

hm3

• Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

behavior/neurological

impaired swimming ( J:32517 )

• at P21-P28, most homozygotes exhibit a poor swimming behavior that is not improved through repeated training

• i.p. administration of the 5-HT receptor agonist, DOI hydrochloride, transiently improves swimming behavior in 85% of poor swimmers

increased locomotor activity ( J:32517 )

• at P21-P28, most homozygotes display a 2-3-fold increase in locomotive activities relative to wild-type mice

• homozygotes keep on moving even during daytime

• i.p. administration of the dopamine receptor agonist, LY171555 (0.5 mg/kg, BW), prevents emergence of hyperlocomotion in mutant mice, with no behavioral changes in wild-type or heterozygous mice

increased stereotypic behavior ( J:32517 )

• at P21-P28, most homozygotes display stereotyped turning behavior, such as purposeless movements

abnormal circadian behavior ( J:32517 )

• homozygotes display an ambiguous circadian rhythm

homeostasis/metabolism

decreased dopamine level ( J:32517 )

• homozygotes with abnormal behavior exhibit a significantly reduced dopamine turnover rate in the striatum and hippocampus

abnormal serotonin level ( J:32517 )

• homozygotes with abnormal behavior exhibit a decreased serotonin (5-HT) turnover rate in the cerebral cortex and hippocampus

nervous system

abnormal CNS synaptic transmission ( J:32517 )

• homozygotes with abnormal behavior display reduced serotonin (5-HT) and dopamine (DA) neurotransmission in the cerebral cortex, hippocampus, and striatum