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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnctm1Sia
targeted mutation 1, Shinichi Aizawa
MGI:2148540
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnctm1Sia/Tnctm1Sia involves: BALB/c * C57BL/6 * CBA MGI:2174672
hm2
Tnctm1Sia/Tnctm1Sia involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5524053
hm3
Tnctm1Sia/Tnctm1Sia involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj MGI:3700279


Genotype
MGI:2174672
hm1
Allelic
Composition
Tnctm1Sia/Tnctm1Sia
Genetic
Background
involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnctm1Sia mutation (11 available); any Tnc mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no histological or anatomical defects were detected in any tissue
• no changes in the distribution of extracellular matrix proteins such as fibronectin, laminin, collagen or proteoglycans




Genotype
MGI:5524053
hm2
Allelic
Composition
Tnctm1Sia/Tnctm1Sia
Genetic
Background
involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnctm1Sia mutation (11 available); any Tnc mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• homozygotes can hear on a gross level, as shown by a Preyer reflex, and display normal cochlear anatomy as well as open fluid spaces in the adult organ of Corti
• at P3, preliminary studies of neurofilaments indicate that afferent innervation is present in the cochlear outer hair cell region




Genotype
MGI:3700279
hm3
Allelic
Composition
Tnctm1Sia/Tnctm1Sia
Genetic
Background
involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnctm1Sia mutation (11 available); any Tnc mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygotes display an ambiguous circadian rhythm
• at P21-P28, most homozygotes exhibit a poor swimming behavior that is not improved through repeated training
• i.p. administration of the 5-HT receptor agonist, DOI hydrochloride, transiently improves swimming behavior in 85% of poor swimmers
• at P21-P28, most homozygotes display a 2-3-fold increase in locomotive activities relative to wild-type mice
• homozygotes keep on moving even during daytime
• i.p. administration of the dopamine receptor agonist, LY171555 (0.5 mg/kg, BW), prevents emergence of hyperlocomotion in mutant mice, with no behavioral changes in wild-type or heterozygous mice
• at P21-P28, most homozygotes display stereotyped turning behavior, such as purposeless movements

homeostasis/metabolism
• homozygotes with abnormal behavior exhibit a significantly reduced dopamine turnover rate in the striatum and hippocampus
• homozygotes with abnormal behavior exhibit a decreased serotonin (5-HT) turnover rate in the cerebral cortex and hippocampus

nervous system
• homozygotes with abnormal behavior exhibit a decreased serotonin (5-HT) turnover rate in the cerebral cortex and hippocampus
• homozygotes with abnormal behavior display reduced serotonin (5-HT) and dopamine (DA) neurotransmission in the cerebral cortex, hippocampus, and striatum





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory