All Phenotypes Gja3<tm1Scr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gja3^tm1Scr
targeted mutation 1, The Scripps Research Institute
MGI:2136656

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr	involves: 129 * C3H/HeJ * C57BL/6J	MGI:3811922
cx2	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:3811924
cx3	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J	MGI:3811920
cx4	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G	involves: 129S4/SvJae * CWD/LeAgl * SJL/J	MGI:5489762

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8^tm1Scr
Genetic Background	involves: 129 * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^L1 mutation (1 available); any Gja8 mutation (33 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^tm1Scr/Gja8^tm1Scr
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^tm1Scr mutation (0 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:108522 )

N	• normal lens fiber cell elongation

nuclear cataract ( J:108522 )

• large nuclear cataracts 3 weeks of age

microphthalmia ( J:108522 )

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^L1/Gja8⁺
Genetic Background	involves: 129S4/SvJae * C3H/HeJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:108522 )

• cystic lumen

nuclear cataract ( J:108522 )

• nuclear rather than whole cataracts

Allelic Composition	Gja3^tm1Scr/Gja3^tm1Scr Gja8^R205G/Gja8^R205G
Genetic Background	involves: 129S4/SvJae * CWD/LeAgl * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja3^tm1Scr mutation (0 available); any Gja3 mutation (17 available)
Gja8^R205G mutation (1 available); any Gja8 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

vision/eye phenotype ( J:195727 )

N	• mice exhibit normal lens periphery and lens fiber unlike in Gja8^Nm2249 homozygotes

nuclear cataract ( J:195727 )

• dense

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23