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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fgfr3tm2Wei
targeted mutation 2, Weizmann Institute of Science
MGI:2135636
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Fgfr3tm2Wei/Fgfr3+ involves: 129S1/Sv * 129X1/SvJ * MF1 MGI:3639744


Genotype
MGI:3639744
ht1
Allelic
Composition
Fgfr3tm2Wei/Fgfr3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr3tm2Wei mutation (0 available); any Fgfr3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Anatomical defects of the Fgfr3tm2Wei/Fgfr3+ mouse

growth/size/body
• rounded head is seen as early as 10 days of age
• incisors do not align properly and protrude because of changes in the skull
• overgrowth or incisor teeth
• weight is half or less that of wild-type
• when teeth are shortened to allow normal food intake, the weight still does not exceed 60% of the wild-type

skeleton
• rounding of the braincase
• extreme shortening and distortion of the frontal bone
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull
• distortion of the parietal bones
• distortion of the maxilla
• incisors do not align properly and protrude because of changes in the skull
• overgrowth or incisor teeth
• extreme shortening of the nasal bone
• incisors do not align properly and protrude because of changes in the skull
• proliferative zone is devoid of the characteristic chondrocyte columns
• hypertrophic zone is considerably reduced or absent
• shortening and disorganization of the growth plate
• shortening and disorganization of the growth plate
• show an overt anterior gibbus probably due to the nearly perpendicular angle between the skull and the cervical vertebrae

craniofacial
• rounding of the braincase
• extreme shortening and distortion of the frontal bone
• ventral and anterior shift of the interparietal and occipital bones which brings the foramen magnum to the base of the skull
• distortion of the parietal bones
• distortion of the maxilla
• incisors do not align properly and protrude because of changes in the skull
• overgrowth or incisor teeth
• extreme shortening of the nasal bone
• incisors do not align properly and protrude because of changes in the skull

limbs/digits/tail

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondroplasia; ACH 100800 J:54829





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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory