Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1Tng mutation
(1 available);
any
Cxcl12 mutation
(24 available)
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reproductive system
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• migration of primordial germ cells in the hindgut and mesentery is normal however the number of cells in the genital ridges at E10.5 is reduced in homozygotes
• proliferation of germ cells that reach the genital ridges is normal
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cellular
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• migration of primordial germ cells in the hindgut and mesentery is normal however the number of cells in the genital ridges at E10.5 is reduced in homozygotes
• proliferation of germ cells that reach the genital ridges is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1Tng mutation
(1 available);
any
Cxcl12 mutation
(24 available)
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integument
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• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice
• however, vascular density is normal
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mortality/aging
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• about half of the homozygous embryos die between E15.5 and E18.5
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• homozygotes die within 1 hour of birth
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cardiovascular system
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• mice exhibit a failure of nerve-vessel alignment in developing limb skin compared with wild-type mice
• however, vascular density is normal
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• the large vessels of the stomach arising from the mesenchymal vessels are absent
• the small vascular network that surrounds the stomach and the vasculature of other organs are normal
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• disorganized branching patterns in developing limb skin
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• reduced smooth muscle cell coverage of small diameter branched vessels
• however, coverage of large diameter veins is normal
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• homozygotes have a defect in the membranous portion of the ventricular septum
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hematopoietic system
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• pro-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice
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• at E18.5 in the fetal liver, myelopoiesis is reduced identical to the phenotype in Cxcr4tm1Qma homozygotes
• at E18.5, a marked reduction in myeloid cells is also seen in the spleen and myeloid cells are virtually absent from the bone marrow
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• on E17.5 hematopoietic cells are virtually absent from the bone marrow
(J:34750)
• B-cell lymphopoiesis is also absent in the bone marrow
(J:34750)
• at E18.5, myeloid cells are virtually absent from the bone marrow
(J:49070)
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• by E16.5 pre-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice
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nervous system
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• mice exhibit normal innervation accompanied by migrating Schwann cells
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• at E18.5, the cerebellum is disorganized
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• at E18.5, the external granule cell layer is attenuated
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immune system
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• pro-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice
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• at E18.5 in the fetal liver, myelopoiesis is reduced identical to the phenotype in Cxcr4tm1Qma homozygotes
• at E18.5, a marked reduction in myeloid cells is also seen in the spleen and myeloid cells are virtually absent from the bone marrow
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• by E16.5 pre-B cell numbers are severely reduced in the fetal livers of mutants compared to wild-type mice
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muscle
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• reduced smooth muscle cell coverage of small diameter branched vessels
• however, coverage of large diameter veins is normal
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hematopoietic system
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• the numbers of colony-forming cells and KSL cells are increased in the blood and spleen, demonstrating constitutive HPC mobilization, compared with control mice
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• modest decrease in the absolute number
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• increased cycling of more mature KSL progenitors in the blood
• however, hematopoietic stem cell cycling is normal
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immune system
hematopoietic system
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N |
• hematopoietic stem cell numbers and cycling are normal
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• bone marrow cells exhibit multilineage long-term repopulating defects
• however, self-renewal capacity is restored by transplantation into a wild-type environment
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hematopoietic system
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• reduced B cell lymphoid progenitors
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• bone marrow cells exhibit multilineage long-term repopulating defects
• however, self-renewal capacity is restored by transplantation into a wild-type environment
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• increased cycling of hematopoietic stem cells and more mature KSL progenitors in the spleen
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immune system
hematopoietic system
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N |
• mice exhibit normal hematopoietic stem cell and lymphoid progenitors morphology and physiology
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immune system
Analysis Tools