Analysis Tools
mortality/aging
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• embryos die between E11.5 and E13.5
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liver/biliary system
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• E12.5 embryos are smaller than controls
• these livers are almost completely devoid of hematopoietic cells, and their sinusoidal cavities are empty
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hematopoietic system
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• hematopoietic cells are absent in the E12.5 liver but the formation of primitive nucleated erythrocytes in the yolk sac is normal
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• hematopoietic cells are absent in the E12.5 liver
• fetal liver cells are unable to produce any myeloid or erythroid colonies in vitro
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cardiovascular system
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• severe intraventricular bleeding is seen in about half of E12.5 embryos
• hemorrhage is observed in the nerve cell layer as foci of various sizes, some appearing to extend into and lift the ependymal epithelium
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• severe spinal canal bleeding is seen in about half of E12.5 embryos
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embryo
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• hematopoietic cells are absent in the E12.5 liver but the formation of primitive nucleated erythrocytes in the yolk sac is normal
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nervous system
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• severe intraventricular bleeding is seen in about half of E12.5 embryos
• hemorrhage is observed in the nerve cell layer as foci of various sizes, some appearing to extend into and lift the ependymal epithelium
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• severe spinal canal bleeding is seen in about half of E12.5 embryos
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