Mouse Genome Informatics
hm1
    F9tm1Dws/F9tm1Dws
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)

hematopoietic system
• following bleeding experiments (J:166332)


Mouse Genome Informatics
ot2
    F9tm1Dws/Y
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)

hematopoietic system
• following bleeding experiments (J:166332)


Mouse Genome Informatics
ot3
    F9tm1Dws/Y
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates (J:44497)

homeostasis/metabolism
• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed (J:44497)
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized (J:44497)

cardiovascular system
N
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition (J:80537)
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads (J:44497)
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature (J:44497)
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed (J:44497)
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates (J:44497)

hematopoietic system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)

immune system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)

Mouse Models of Human Disease
OMIM IDRef(s)
Hemophilia B; HEMB 306900 J:44497