About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
F9tm1Dws
targeted mutation 1, Darrel W Stafford
MGI:1932297
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
F9tm1Dws/F9tm1Dws involves: 129P2/OlaHsd MGI:4847609
ot2
F9tm1Dws/Y involves: 129P2/OlaHsd MGI:4847610
ot3
F9tm1Dws/Y involves: 129P2/OlaHsd * C57BL/6 MGI:3662691


Genotype
MGI:4847609
hm1
Allelic
Composition
F9tm1Dws/F9tm1Dws
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation (1 available); any F9 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)

hematopoietic system
• following bleeding experiments (J:166332)
• following bleeding experiments (J:166332)




Genotype
MGI:4847610
ot2
Allelic
Composition
F9tm1Dws/Y
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation (1 available); any F9 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice (J:166332)

hematopoietic system
• following bleeding experiments (J:166332)
• following bleeding experiments (J:166332)




Genotype
MGI:3662691
ot3
Allelic
Composition
F9tm1Dws/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation (1 available); any F9 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates (J:44497)
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates (J:44497)

homeostasis/metabolism
• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed (J:44497)
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized (J:44497)
• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed (J:44497)
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized (J:44497)

cardiovascular system
N
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition (J:80537)
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition (J:80537)
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads (J:44497)
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature (J:44497)
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed (J:44497)
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads (J:44497)
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature (J:44497)
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed (J:44497)
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates (J:44497)
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates (J:44497)

hematopoietic system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)

immune system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss (J:44497)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemophilia B; HEMB 306900 J:44497





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory