Mouse Genome Informatics
hm1
    F9tm1Dws/F9tm1Dws
involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice

hematopoietic system
• following bleeding experiments


Mouse Genome Informatics
ot2
    F9tm1Dws/Y
involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation

homeostasis/metabolism
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
• mice bleed for more than 10 minutes with a secondary bleeding challenge compared with 2.7 minutes for similarly treated wild-type mice

hematopoietic system
• following bleeding experiments


Mouse Genome Informatics
ot3
    F9tm1Dws/Y
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates

homeostasis/metabolism
• male hemizygotes display a severe hemophilia B phenotype with reduced plasma clotting activity although an 8% residual activity is observed
• when their tails are cut, male hemizygotes bleed and die if the wound is not cauterized

cardiovascular system
N
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition
• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed
• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates

hematopoietic system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss

immune system
• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss

Mouse Models of Human Disease
OMIM IDRef(s)
Hemophilia B; HEMB 306900 J:44497