Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation
(1 available);
any
F9 mutation
(8 available)
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mortality/aging
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• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
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homeostasis/metabolism
hematopoietic system
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• following bleeding experiments
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Allelic Composition |
F9tm1Dws/Y
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Genetic Background |
involves: 129P2/OlaHsd |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation
(1 available);
any
F9 mutation
(8 available)
|
|
|
mortality/aging
|
• rebleeding in 4 of 9 mice results in immobility and cardiovascular instability requiring euthanasia after less than 2 hours of observation
|
homeostasis/metabolism
hematopoietic system
|
• following bleeding experiments
|
Allelic Composition |
F9tm1Dws/Y
|
|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F9tm1Dws mutation
(1 available);
any
F9 mutation
(8 available)
|
|
|
mortality/aging
|
• male hemizygotes survive well if no injury occurs but occasionally exhibit sudden death during growth, mostly as a result of internal hemorrhage after normal fighting with littermates
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homeostasis/metabolism
cardiovascular system
N |
• at 13 weeks of age, prohemorrhagic male hemizygotes display normal hearts with no evidence of hemosiderin deposition
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• male hemizygotes are grossly normal but display spontaneous bleeding, as shown by hemorrhagic swelling of the top of the feet or of the footpads or the presence of pale footpads
• at autopsy, male hemizygotes show massive hemorrhages, mostly subcutaneous or in the dorsal surface musculature
• intra-cranial hemorrhages, hemorrhages in the axilliary and inguinal areas, hemorrhages around the salivary glands, and hemorrhages in the pericardium are also observed
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• male hemizygotes display fatal internal hemorrhage after normal fighting with littermates
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hematopoietic system
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• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
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immune system
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• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
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growth/size/body
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• male hemizygotes commonly exhibit splenomegaly, indicating anemia caused by blood loss
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