Phenotypes associated with this allele

• Allele Symbol: Vtn^tm1Dgi
• Allele Name: targeted mutation 1, David Ginsburg
• Allele ID: MGI:1931522
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vtn^tm1Dgi/Vtn^tm1Dgi	B6.129S2-Vtn^tm1Dgi	MGI:3796989
hm2	Vtn^tm1Dgi/Vtn^tm1Dgi	involves: 129S2/SvPas * C57BL/6 * DBA/2J	MGI:2174805

Genotype
MGI:3796989

hm1

• Allelic Composition: Vtn^tm1Dgi/Vtn^tm1Dgi
• Genetic Background: B6.129S2-Vtn^tm1Dgi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:134443 )

• in a model of ferric chloride induced vessel injury, mutants exhibit unstable thrombi and a greater number of emboli

• in a cremaster muscle arteriole mode where vessel injury is induced by a nitrogen dye laser, mutants exhibit fewer platelets, lower fibrin content, and unstable fibrin within the thrombi compared to wild-type

abnormal platelet aggregation ( J:134443 )

• early platelet adhesion is not affected, however the second wave of thrombin-induced aggregation of gel-filtered platelets is abolished at a low concentration of thrombin

• mutant platelet-rich plasma shows a 32% increase in adenosine diphosphate-induced platelet aggregation in vitro compared to wild-type

• whole blood of mutants exhibits an increase in shear-induced platelet aggregation

abnormal response to injury ( J:134443 )

• in a model of ferric chloride induced vessel injury, mutants exhibit unstable thrombi and a greater number of emboli

• vessel occlusion is delayed and frequent vessel re-opening occurs in mutants where vessel injury was induced with ferric chloride

• in a cremaster muscle arteriole mode where vessel injury is induced by a nitrogen dye laser, mutants exhibit fewer platelets, lower fibrin content, and unstable fibrin within the thrombi compared to wild-type

hematopoietic system

abnormal platelet aggregation ( J:134443 )

• early platelet adhesion is not affected, however the second wave of thrombin-induced aggregation of gel-filtered platelets is abolished at a low concentration of thrombin

• mutant platelet-rich plasma shows a 32% increase in adenosine diphosphate-induced platelet aggregation in vitro compared to wild-type

• whole blood of mutants exhibits an increase in shear-induced platelet aggregation

Genotype
MGI:2174805

hm2

• Allelic Composition: Vtn^tm1Dgi/Vtn^tm1Dgi
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2J

normal phenotype

no abnormal phenotype detected ( J:30296 )

• viable and fertile with no differences in blood counts or autopsy findings; histological analysis did not detect any abnormalities in the nervous system, heart, lung, liver and kidney