Phenotypes associated with this allele
immune system
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• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection
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hematopoietic system
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• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection
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immune system
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• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age
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mortality/aging
hematopoietic system
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N |
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1b-tm1Bpe mutation
(9 available);
any
H2-D1 mutation
(45 available)
H2-K1b-tm1Bpe mutation
(9 available);
any
H2-K1 mutation
(59 available)
Klra1tm1.1Wyok mutation
(0 available);
any
Klra1 mutation
(17 available)
Tg(H2-Dd)28Bee mutation
(0 available)
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hematopoietic system
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N |
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
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• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele ( MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele ( MGI:6196216)
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immune system
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• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele ( MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele ( MGI:6196216)
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mortality/aging
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• survive infection with Lymphocytic Choriomeningitis Virus
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immune system
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• numbers increase in parallel to decrease in CD8+ cells
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• 90% reduction of single positive CD8 peripheral T-cells
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• CD8+ TCRalpha/beta T-cells not present
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• survive infection with Lymphocytic Choriomeningitis Virus
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nervous system
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N |
• normal gross cerebellar development
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• increased glutamate transients in climbing fiber synaptic clefts
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• lower threshold for induction if climbing fibers are involved in induction
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• larger paired pulse ratio when paired stimuli are applied to climbing fibers are separated by 50-100 msec
• significantly increased second excitatory postsynaptic current
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behavior/neurological
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• performance in rotarod tests is significantly better than controls on the third day of testing
• testing repeated after 2 weeks of rest and then after another 4 months of rest indicate much better task retention than for controls
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hematopoietic system
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• numbers increase in parallel to decrease in CD8+ cells
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• 90% reduction of single positive CD8 peripheral T-cells
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• CD8+ TCRalpha/beta T-cells not present
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immune system
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• almost no CD8+ T lymphocytes
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hematopoietic system
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• almost no CD8+ T lymphocytes
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Analysis Tools