Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2.1Gsc mutation
(1 available);
any
Nr3c1 mutation
(34 available)
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mortality/aging
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• all mice die shortly after birth
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endocrine/exocrine glands
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• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice
• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice
• however, the number of chromaffin cells, volume density and granule diameter are normal
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homeostasis/metabolism
hematopoietic system
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• E14.5 fetal liver cultures fail to exhibit outgrowths of erythroid progenitor cells as do wild-type livers
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nervous system
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• adrenal chromaffin cells exhibit reduced TH, PNMT and chromogranin B immunoreactivity compared to in wild-type mice
• adrenal chromaffin cells fail to express sympathetic neuronal markers unlike in wild-type mice
• however, the number of chromaffin cells, volume density and granule diameter are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2.1Gsc mutation
(1 available);
any
Nr3c1 mutation
(34 available)
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skeleton
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N |
• relative to wild-type, mice do not display differences in cartilage or calcified tissue; mice show similar bone mineral densities as wild-type and have no gross alterations in growth plate dimension or amount of calcified bone
• osteoblast differentiation is unaffected by this mutation
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• unlike wild-type cells, differentiation is not repressed by dexamethasone
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type
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cellular
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• unlike wild-type cells, differentiation is not repressed by dexamethasone
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• proliferation of preconfluent preosteoblasts from neonatal calvaria is lower in culture compared to wild-type cells; numbers of postconfluential cells are not affected by dexamethasone treatment in contrast to reduced numbers of wild-type cells in culture
• treatment with dexamethasone does not affect mutant cells but completely inhibits osteoblast proliferation in cultures of wild-type cells; apoptosis is not induced with dexamethasone treatment in contrast to wild-type cultures
• alkaline phosphatase activity and matrix mineralization in unaffected by dexamethasone treatment in mutants in contrast to the inhibition observed in wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr3c1tm2.1Gsc mutation
(1 available);
any
Nr3c1 mutation
(34 available)
|
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immune system
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• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice
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• when subjected to a MOG induced model of experimental autoimmune encephalitis, mice exhibit increased clinical score, resistance to the beneficial effects of dexamethasone treatment and increased T cell and macrophage infiltration compared to in similarly treated wild-type mice
• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity
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nervous system
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• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity
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cardiovascular system
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• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity
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cellular
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• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice
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hematopoietic system
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• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice
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Analysis Tools