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Allele Symbol Allele Name Allele ID |
Tg(WapNotch4)10Rnc transgene insertion 10, Robert Callahan MGI:1930202 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands
• pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds
• acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina
• in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund
• however, mammary ductal growth is unaffected in virgin females
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• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months
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• parous females fail to lactate
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• gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands
• pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds
• acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina
• in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund
• however, mammary ductal growth is unaffected in virgin females
|
|
• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months
|
|
• most tumor-bearing females, irrespective of breeding history, develop metastatic lung tumors
|
|
|
• gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands
• pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds
• acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina
• in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund
• however, mammary ductal growth is unaffected in virgin females
|
|
• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months
|
|
|
• parous females fail to lactate
|
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• most tumor-bearing females, irrespective of breeding history, develop metastatic lung tumors
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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