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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Trp53R172H)8512Jmr
transgene insertion 8512, Jeffrey Rosen
MGI:1929642
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr MGI:3799373
cx2
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?
involves: C57BL/6 * FVB MGI:3761175
cx3
Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
involves: FVB MGI:3799447
tg4
Tg(Trp53R172H)8512Jmr/0 involves: FVB MGI:3799369


Genotype
MGI:3799373
cx1
Allelic
Composition
Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
Genetic
Background
C.FVB-Tg(MMTVneu)202Mul Tg(Trp53R172H)8512Jmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice

endocrine/exocrine glands
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

respiratory system
• mice exhibit lung metastases

integument
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age

mortality/aging
• most mice die by 11 to 12 weeks of age due to overgrowth of the poorly differentiated and invasive carcinoma and lung metastases
• all mice die prior to 18 weeks of age

neoplasm
• mice develop progressive parotid gland carcinomas beginning after 3 weeks of age that occur earlier in male mice
• by week 3, female mice exhibit multifocal hyperplastic foci that progress into in situ lobular carcinoma and invasive carcinoma in mice that survive beyond 14 weeks of age
• mice exhibit lung metastases




Genotype
MGI:3761175
cx2
Allelic
Composition
Tg(MMTV-neu/OT-I/OT-II)CBnel/?
Tg(Trp53R172H)8512Jmr/?
Genetic
Background
involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-neu/OT-I/OT-II)CBnel mutation (1 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

integument
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

neoplasm
• 80% of females develop adencarcinomas by 6-10 months of age; mice generally have 1or two tumors
• tumors are highly mitotic with glandular differentiation in ~30% of cases; ~90% of tumors have minimal necrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:122846




Genotype
MGI:3799447
cx3
Allelic
Composition
Tg(MMTVneu)202Mul/0
Tg(Trp53R172H)8512Jmr/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVneu)202Mul mutation (2 available)
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

endocrine/exocrine glands
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

neoplasm
• mice develop mammary gland tumors at 112 days of age whereas mice expressing Tg(MMTVneu)202Mul alone develop mammary gland tumors at 163 days of age and mice expressing Tg(Trp53R172H)8512Jmr alone do not develop mammary gland tumors up 300 days
• the median age of mammary gland tumor development is 154 days compared to 234 days in mice expressing only Tg(MMTVneu)202Mul alone
• tumors that arise have greater cytological variability and larger cellular and nuclear size than in tumors from mice expressing Tg(MMTVneu)202Mul alone
• tumors exhibit higher apoptosis and mitosis rates that in tumors from mice expressing Tg(MMTVneu)202Mul alone

cellular
• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy
• tumors exhibit aneuploidy and tetraploidy unlike in tumors from mice expressing Tg(MMTVneu)202Mul alone that are euploidy




Genotype
MGI:3799369
tg4
Allelic
Composition
Tg(Trp53R172H)8512Jmr/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53R172H)8512Jmr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

neoplasm
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

cellular
• tumor cells exhibit an increase in genomic instability (tetraploid and aneuploid) compared to tumor cells in wild-type mice

endocrine/exocrine glands
N
• mammary gland development is normal
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

homeostasis/metabolism
• despite normal incidence of spontaneous tumors, mice exhibit an increase in rate of development and tumor burden of DMBA-induced mammary carcinomas compared to similarly treated wild-type mice
• DMBA induces type B mammary gland adenocarcinomas and adenomas compared to carcinomas and adenocarcinomas that develop in similarly treated wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:46426





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory