All Phenotypes Grin2a<tm1Mim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grin2a^tm1Mim
targeted mutation 1, Masayoshi Mishina
MGI:1928285

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin2a^tm1Mim/Grin2a^tm1Mim	B6.Cg-Grin2a^tm1Mim	MGI:4943913
hm2	Grin2a^tm1Mim/Grin2a^tm1Mim	involves: C57BL/6 * CBA	MGI:2175052
cx3	Grin2a^tm1Mim/Grin2a^tm1Mim Grin2c^tm1Mwa/Grin2c^tm1Mwa	involves: C57BL/6 * CBA	MGI:3055023

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim
Genetic Background	B6.Cg-Grin2a^tm1Mim

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased startle reflex ( J:89405 )

• enhanced startle response at sound levels of 100 - 110 dB

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:22295 )

• take a longer time to reach the platform on the first block of trails on a visible-platform task; subsequently they perform similiarly to wild-type

• take significantly longer to locate the hidden platform in the hidden-platform task

• in the transfer test, homozygotes spend a significantly shorter time searching in the trained quadrant and cross the trained spot less often than wild-type

jumpy ( J:22295 )

• jumpy

nervous system

reduced NMDA-mediated synaptic currents ( J:22295 )

• significant reduction of the NMDA receptor channel current, however no differences in the current-voltage relationships of the NMDA receptor channel currents and the reversal potential

reduced long-term potentiation ( J:22295 )

• reduced LTP at the hippocampal CA1 synapses, however histological examination of various brain regions shows no abnormalities

Allelic Composition	Grin2a^tm1Mim/Grin2a^tm1Mim Grin2c^tm1Mwa/Grin2c^tm1Mwa
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin2a^tm1Mim mutation (1 available); any Grin2a mutation (66 available)
Grin2c^tm1Mwa mutation (0 available); any Grin2c mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:92648 )

• a mild motor coordination impairment is seen in the rotating rod test at high speeds

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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