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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2-Ab1tm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:1927483
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2-Ab1tm1Doi/H2-Ab1tm1Doi involves: 129S2/SvPas MGI:4949107
hm2
H2-Ab1tm1Doi/H2-Ab1tm1Doi involves: 129S2/SvPas * C57BL/6 MGI:2386103
hm3
H2-Ab1tm1Doi/H2-Ab1tm1Doi involves: 129S2/SvPas * C57BL/6 * NOD/Lt MGI:3640345
ht4
H2-Ab1tm1Doi/H2-Ab1+ involves: 129S2/SvPas * C57BL/6 * NOD/Lt MGI:3640346
cx5
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal
involves: 129P2/OlaHsd * 129S2/SvPas MGI:3770644
cx6
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
involves: 129P2/OlaHsd * 129S2/SvPas MGI:4949108


Genotype
MGI:4949107
hm1
Allelic
Composition
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in hippocampal neurogenesis

cellular
• decrease in hippocampal neurogenesis




Genotype
MGI:2386103
hm2
Allelic
Composition
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

reproductive system
• impaired breeding performance

immune system
• peripheral CD4+ cells are larger in size than normal
• thymus CD4+ cells are cortical cells and smaller than normal in size
• in spleen cells, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection (J:64283)
• proportional increase of CD8+ cell number in periphery (J:65736)
• increased numbers in the thymus sometimes but not always (J:65736)
• CD4+ T cell population in the spleens are reduced 3-fold compared to Ciita-deficient mice and even more greatly reduced compared to wild-type (J:51885)
• massive reduction of peripheral CD4+ cells to 3-7% normal numbers (J:65736)
• moderate reduction of CD4+ cells in the thymus to 17-30% of normal (J:65736)
• in spleen cells, there is a 4.5-fold increase in the number of CD4+CD69 high cells in mutants at 8 weeks after parasite infection
• reduced follicular zone at 13 weeks
• absent but B cell differentiation not grossly disturbed
• very few CD4+ cells in the periarteriolar sheath of the spleen
• normal numbers of CD4+ cells in the B cell follicles
• very few CD4+ cells in the paracortex of the lymph nodes
• reduced numbers of cells expressing IgD at 10 weeks
• 10-100 fold reduction in IgG1 levels in the serum
• no T-cell dependent antigen responses
• double positive T cells express higher than normal levels of CD4
• peripheral cells express reduced levels of CD4 and TCR AlphaBeta but high levels of CD44
• thymus CD4 single positive cells express very low but detectable levels of CD8
• higher than normal numbers in thymus express TCR AlphBeta but at lower levels
• spleen and lymph node cells produced no measurable cytokines at 8 weeks after infection with parasite antigens
• after infection with L. amazonensis, mice show no lesion development up to 11 weeks post infection, reduced cellular infiltration, lower parasite load and fewer cells in the popliteal lymph nodes draining the infected foots
• after infection with L. amazonensis, infected cells contained tightly packed organisms with few parasitophorous vacuole visible whereas infected macrophages in wild-type mice contained only a few organisms which are preferentially located at the edge of parasitophorous vacuoles
• lesions become significantly larger with higher parasitic burdens 16 weeks after L. major infection, compared with lesion resolution in wild-type

hematopoietic system
• in spleen cells, a slight increase in the number of CD8+ T cells compared to wild-type is seen pre- and post-infection (J:64283)
• proportional increase of CD8+ cell number in periphery (J:65736)
• increased numbers in the thymus sometimes but not always (J:65736)
• CD4+ T cell population in the spleens are reduced 3-fold compared to Ciita-deficient mice and even more greatly reduced compared to wild-type (J:51885)
• massive reduction of peripheral CD4+ cells to 3-7% normal numbers (J:65736)
• moderate reduction of CD4+ cells in the thymus to 17-30% of normal (J:65736)
• in spleen cells, there is a 4.5-fold increase in the number of CD4+CD69 high cells in mutants at 8 weeks after parasite infection
• reduced follicular zone at 13 weeks
• absent but B cell differentiation not grossly disturbed
• very few CD4+ cells in the periarteriolar sheath of the spleen
• normal numbers of CD4+ cells in the B cell follicles
• reduced numbers of cells expressing IgD at 10 weeks
• 10-100 fold reduction in IgG1 levels in the serum
• no T-cell dependent antigen responses
• double positive T cells express higher than normal levels of CD4
• peripheral cells express reduced levels of CD4 and TCR AlphaBeta but high levels of CD44
• thymus CD4 single positive cells express very low but detectable levels of CD8
• higher than normal numbers in thymus express TCR AlphBeta but at lower levels




Genotype
MGI:3640345
hm3
Allelic
Composition
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * NOD/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks

immune system
• 10-11 week old mice of the fourth backcross generation to NOD/Lt mice are completely free of insulitis compared to NOD controls which develop insulitis by 6-8 weeks




Genotype
MGI:3640346
ht4
Allelic
Composition
H2-Ab1tm1Doi/H2-Ab1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * NOD/Lt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• heterozygous mice show insulitis less frequently and less severely than homozygotes

immune system
• heterozygous mice show insulitis less frequently and less severely than homozygotes




Genotype
MGI:3770644
cx5
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Lattm1Mal/Lattm1Mal
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (36 available); any B2m mutation (46 available)
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
Lattm1Mal mutation (0 available); any Lat mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• pathological inflammatory phenotype of Lattm1Mal homozygotes is absent in these mice
• in both the thymus and spleen
• in both the thymus and spleen

hematopoietic system
• in both the thymus and spleen
• in both the thymus and spleen




Genotype
MGI:4949108
cx6
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (36 available); any B2m mutation (46 available)
H2-Ab1tm1Doi mutation (15 available); any H2-Ab1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• decrease in hippocampal neurogenesis

cellular
• decrease in hippocampal neurogenesis





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory