All Phenotypes Nf2<tm2.1Gth> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nf2^tm2.1Gth
targeted mutation 2.1, Gilles Thomas
MGI:1926957

Summary

2 genotypes

Allelic Composition	Nf2^tm2.1Gth/Nf2^tm2.1Gth
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2.1Gth mutation (0 available); any Nf2 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die prior to E9.5

Allelic Composition	Nf2^tm2.1Gth/Nf2⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2.1Gth mutation (0 available); any Nf2 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:63264 )

N	• mice do not develop schwannoma, meningioma or other NF2 associated tumors

• in 14% in mice

increased fibrosarcoma incidence ( J:63264 )

• in 43% of mice with 1 of 3 metastasizing to the liver

increased osteosarcoma incidence ( J:63264 )

• in 43% of mice

increased osteoma incidence ( J:63264 )

• 29% of mice develop osteoma

respiratory system

• in 14% in mice

skeleton

increased osteosarcoma incidence ( J:63264 )

• in 43% of mice

increased osteoma incidence ( J:63264 )

• 29% of mice develop osteoma

nervous system

nervous system phenotype ( J:63264 )

N	• mice exhibit normal Schwann cell proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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