Analysis Tools
behavior/neurological
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• mutant mice lose the Preyer reflex between 4.5 and 10 months of age
• mutant and control mice show a robust reflex at 2.5 months
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• mice show an abnormal reaching response when suspended by tail in air at 2.5 months of age
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• significant deterioration at 4.5 months of age
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head tossing
(
J:64900
)
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• headtossing begins at age 4-6 weeks
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retropulsion
(
J:64900
)
hearing/vestibular/ear
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• the mutant cochleas appear very immature
• a developmental delay is apparent in stereocilia
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• abnormal development of stereocilla in the cochlea is detectable as early as birth
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• reported degeneration of outer and inner hair cells
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• reported degeneration of vestibular hair cells
• the saccular and utricular otoliths are present and normal
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nervous system
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• the mutant cochleas appear very immature
• a developmental delay is apparent in stereocilia
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• abnormal development of stereocilla in the cochlea is detectable as early as birth
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• reported degeneration of outer and inner hair cells
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• reported degeneration of vestibular hair cells
• the saccular and utricular otoliths are present and normal
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