Phenotypes associated with this allele

• Allele Symbol: Jph2^tm1Hta
• Allele Name: targeted mutation 1, Hiroshi Takeshima
• Allele ID: MGI:1891502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jph2^tm1Hta/Jph2^tm1Hta	involves: 129S4/SvJae * C57BL/6J	MGI:2175084

Genotype
MGI:2175084

hm1

• Allelic Composition: Jph2^tm1Hta/Jph2^tm1Hta
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:63879 )

• cardiac arrest at E10.5 with congested peripheral tissues, followed by autolysis at E11.5

cardiovascular system

abnormal myocardial fiber morphology ( J:63879 )

• the appearance of junctional membrane complexes with a 12nm gap size was reduced to 10% of the control value; the length of the complex was also significantly shorter

abnormal cardiovascular system physiology ( J:63879 )

• calcium imaging analysis on mutant hearts showed that calcium transients were varied in amplitude and were not synchronized with heartbeats in contrast to control hearts where transients in spontaneous oscillations corresponding to rhythmic contractions were nearly constant

irregular heartbeat ( J:63879 )

• weak, irregular heartbeat at E9.5

muscle

abnormal myocardial fiber morphology ( J:63879 )

• the appearance of junctional membrane complexes with a 12nm gap size was reduced to 10% of the control value; the length of the complex was also significantly shorter