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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nrg3ska
scaramanga
MGI:1889610
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nrg3ska/Nrg3ska A/J MGI:4355886


Genotype
MGI:4355886
hm1
Allelic
Composition
Nrg3ska/Nrg3ska
Genetic
Background
A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg3ska mutation (21 available); any Nrg3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mammary gland abnormalities in Nrg3ska/Nrg3ska mice

endocrine/exocrine glands
• Background Sensitivity: 95% of female A/J mice display an altered pattern of mammary gland development compared with C57BL/6 which showed no abnormalities in this study
• 95% of females have abnormal mammary gland development
• misplacement is usually observed with gland #3
• 29% of females observed had this phenotype
• Background Sensitivity: when observed involves only glands of pair #3
• 55% of females observed have this phenotype
• occasionally found between glands #2 and #4 or below #3 gland along the milkline
• 31% of the females observed have this phenotype or supernumerary nipples
• most commonly observed laterally to a #4 gland and displaced away from the mid-line
• connected to distinct underlying ductal systems; not connected to the major ductal system of the normal gland
• easily observed at 21 days of age
• this phenotype or supernumerary mammary glands comprise 31% of mice observed

integument
• Background Sensitivity: 95% of female A/J mice display an altered pattern of mammary gland development compared with C57BL/6 which showed no abnormalities in this study
• 95% of females have abnormal mammary gland development
• misplacement is usually observed with gland #3
• 29% of females observed had this phenotype
• Background Sensitivity: when observed involves only glands of pair #3
• 55% of females observed have this phenotype
• occasionally found between glands #2 and #4 or below #3 gland along the milkline
• 31% of the females observed have this phenotype or supernumerary nipples
• most commonly observed laterally to a #4 gland and displaced away from the mid-line
• connected to distinct underlying ductal systems; not connected to the major ductal system of the normal gland
• easily observed at 21 days of age
• this phenotype or supernumerary mammary glands comprise 31% of mice observed





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory