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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Timp2tm1Pds
targeted mutation 1, Paul D Soloway
MGI:1888708
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Timp2tm1Pds/Timp2tm1Pds B6.129S4-Timp2tm1Pds MGI:3665128
hm2
 		Timp2tm1Pds/Timp2tm1Pds involves: 129S4/SvJae * C57BL/6 MGI:3664798


Genotype
MGI:3665128
hm1
Allelic
Composition		 Timp2tm1Pds/Timp2tm1Pds
Genetic
Background		 B6.129S4-Timp2tm1Pds
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp2tm1Pds mutation (1 available); any Timp2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal cued conditioning behavior ( J:99752 )
• null mice have a deficit in fear-potentiated startle (FPS) vs wild-type; mice generate greater startle responses compared to wild-type mice in presence of tone before fear conditioning (ie. P0 - first testing session)
• all males show an increase in FPS initially (from P0 to P1) but FPS decreases from that point in knockout and knockdown mice; in wild-type and heterozygotes, amplitudes of startle responses continue to increase
• wild-type and heterozygous males acquire conditioned fear over the course of the test, but null and knockdown mice do not
• females do not show any proportional increases in FPS

nervous system
decreased prepulse inhibition ( J:99752 )
• Timp2-null mice have significantly reduced prepulse inhibition (PPI)




Genotype
MGI:3664798
hm2
Allelic
Composition		 Timp2tm1Pds/Timp2tm1Pds
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp2tm1Pds mutation (1 available); any Timp2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased neutrophil cell number ( J:112941 )
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type

immune system
increased neutrophil cell number ( J:112941 )
• at day 7 after treatment, BAL neutrophil percentage and concentration are 3- and 10-fold higher in Timp1-null mice compared to Timp2-null animals; values for Timp2-null mice are similar to wild-type

homeostasis/metabolism
abnormal enzyme/coenzyme activity ( J:64001 )
• activation of proMMP-2 in vivo is dramatically altered with Timp2 deficiency

cardiovascular system
cardiovascular system phenotype ( J:211441 )
N
• following angiotensin II infusion, mice exhibit a normal increase in blood pressure and normal heart rate




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory