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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Inpp5dtm1Dmt
targeted mutation 1, Dan Dumont
MGI:1861956
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Inpp5dtm1Dmt/Inpp5dtm1Dmt B6.129P2/OlaHsd-Inpp5dtm1Dmt MGI:5050832
hm2
Inpp5dtm1Dmt/Inpp5dtm1Dmt involves: 129P2/OlaHsd MGI:3835331
hm3
Inpp5dtm1Dmt/Inpp5dtm1Dmt involves: 129P2/OlaHsd * C57BL/6 MGI:3835336


Genotype
MGI:5050832
hm1
Allelic
Composition
Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic
Background
B6.129P2/OlaHsd-Inpp5dtm1Dmt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1Dmt mutation (3 available); any Inpp5d mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% survival at 6 months of age

respiratory system
• alveoli of 6 month mice are filled with lipid laden macrophage containing eosinophilic Ym1 crystals
• in 50% of mice at 6 months of age

hematopoietic system
• in 4 week old mice
• in 4 week old mice
• reduced mature B cells in bone marrow at 10 weeks of age
• reduced pre-B cells in bone marrow at 10 weeks of age

immune system
• reduced mature B cells in bone marrow at 10 weeks of age
• reduced pre-B cells in bone marrow at 10 weeks of age
• circulating levels elevated
• levels in bone marrow macrophage are normal but elevated in peritoneal and splenic macrophage

homeostasis/metabolism
• circulating levels elevated
• levels in bone marrow macrophage are normal but elevated in peritoneal and splenic macrophage




Genotype
MGI:3835331
hm2
Allelic
Composition
Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1Dmt mutation (3 available); any Inpp5d mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 4-fold at 6 to 8 weeks, 8-fold at 10 weeks, and greater than 10-fold at 16 weeks

mortality/aging
• short life span

immune system
• 4-fold at 6 to 8 weeks, 8-fold at 10 weeks, and greater than 10-fold at 16 weeks
• B220+CD19+sIgM+ B cells are decreased in the bone marrow, and sIgD+sIgM+ B cells are decreased in the secondary lymphatic organs compared to in wild-type mice
• the granulocyte-macrophage/monocyte populations are increased in the spleen compared to in wild-type mice
• mice exhibit an infiltration of monocyte/macrophage and granulocyte cells in the thymus, lymph nodes, liver, kidney, heart, skeletal muscle, connective tissue, exocrine pancreas, and lungs unlike in wild-type mice
• myeloid cells exhibit decreased susceptibility to apoptosis induced by sorbitol, cycloheximide, anisomycin and Fas stimulation compared to wild-type cells

hematopoietic system
• 4-fold at 6 to 8 weeks, 8-fold at 10 weeks, and greater than 10-fold at 16 weeks
• B220+CD19+sIgM+ B cells are decreased in the bone marrow, and sIgD+sIgM+ B cells are decreased in the secondary lymphatic organs compared to in wild-type mice
• the granulocyte-macrophage/monocyte populations are increased in the spleen compared to in wild-type mice
• mice exhibit an infiltration of monocyte/macrophage and granulocyte cells in the thymus, lymph nodes, liver, kidney, heart, skeletal muscle, connective tissue, exocrine pancreas, and lungs unlike in wild-type mice
• myeloid cells exhibit decreased susceptibility to apoptosis induced by sorbitol, cycloheximide, anisomycin and Fas stimulation compared to wild-type cells




Genotype
MGI:3835336
hm3
Allelic
Composition
Inpp5dtm1Dmt/Inpp5dtm1Dmt
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5dtm1Dmt mutation (3 available); any Inpp5d mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• induced thrombi are smaller, contain fewer platelets, and exhibit decreased close cell-cell contact compared to in wild-type mice
• when exposed to thrombin and atroxin, platelets fail to exhibit induced fibrin clot retraction as do wild-type cells
• however, mice are not protected against thromboembolism
• under thrombin stimulation, platelets fail to undergo normal degranulation and form fewer membrane extensions than wild-type cells
• in vitro or under flow, platelet aggregation in response to thrombin, collagen, or thomboxane A2 is decreased compared to controls; platelet aggregates that do form are smaller

hematopoietic system
• under thrombin stimulation, platelets fail to undergo normal degranulation and form fewer membrane extensions than wild-type cells
• in vitro or under flow, platelet aggregation in response to thrombin, collagen, or thomboxane A2 is decreased compared to controls; platelet aggregates that do form are smaller





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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory