All Phenotypes Crygs<Opj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crygs^Opj
opacity due to poor secondary fiber cell junctions
MGI:1861635

Summary

2 genotypes

Allelic Composition	Crygs^Opj/Crygs^Opj
Genetic Background	involves: 102 * C3H/He * T STOCK

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crygs^Opj mutation (2 available); any Crygs mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Progressive cataract development in Crygs^Opj/Crygs⁺ and Crygs^Opj/Crygs^Opj mice

vision/eye

abnormal lens morphology ( J:68109 )

• tangled fibrous masses are seen in the lenses

abnormal lens fiber morphology ( J:68109 )

• swelling and disorganization in the cortical fibers is seen at early stages

• a sharp, distorted boundary between the outer cortical fiber layer and the inner layer is seen

• fiber maturation is disrupted, with loss of nuclei not occuring in a timely fashion, leaving particles in the inner layers of fiber cells

total cataract ( J:34877 , J:68109 )

• total opacity (J:34877)

• progressive with age and more severe than in heterozygote (J:68109)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 20 multiple types		DOID:0110240	OMIM:116100	J:34877 , J:68109

Allelic Composition	Crygs^Opj/Crygs⁺
Genetic Background	involves: 102 * C3H/He * T STOCK

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crygs^Opj mutation (2 available); any Crygs mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Progressive cataract development in Crygs^Opj/Crygs⁺ and Crygs^Opj/Crygs^Opj mice

vision/eye

abnormal lens fiber morphology ( J:34877 )

• poor secondary fiber cell junctions

disorganized secondary lens fibers ( J:21950 )

• described as a secondary lens fiber discontinuity

cataract ( J:34877 , J:68109 )

• opacity (J:34877)

• progressive with age and less severe than homozygote (J:68109)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 20 multiple types		DOID:0110240	OMIM:116100	J:34877 , J:68109

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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