hm1

Iac/Iac
involves: 101 * C3H

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

complete preweaning lethality ( J:6686 )

• homozygotes are lethal

ht2

Iac/Iac⁺
involves: 101 * C3H

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

mortality/aging

premature death ( J:6686 )

• higher mortality

growth/size

decreased body size ( J:6686 )

vision/eye

abnormal pupillary reflex ( J:6686 )

• pupillary reaction is minimal or absent

abnormal pupil morphology ( J:6686 )

• shape of the pupil varies from oval to slit-like

abnormal placement of pupils ( J:9528 )

cataracts ( J:6686 , J:9528 )

• cortical or total opacity; bilateral (J:6686)

coloboma ( J:6686 , J:9528 )

• atypical colobomata often present (J:6686)

microphthalmia ( J:9528 )

craniofacial

abnormal cranium morphology ( J:6686 )

• twisted skull resulting from long teeth

abnormal tooth morphology ( J:6686 , J:9528 )

• long teeth (J:6686)

• long teeth (J:9528)

skeleton

abnormal cranium morphology ( J:6686 )

• twisted skull resulting from long teeth

behavior/neurological

abnormal pupillary reflex ( J:6686 )

• pupillary reaction is minimal or absent