About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Msh5tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:1858057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Msh5tm1Rak/Msh5tm1Rak involves: 129/Sv * C57BL/6J * SJL MGI:2183396
cx2
Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
involves: 129/Sv * C57BL/6 * SJL MGI:2663948


Genotype
MGI:2183396
hm1
Allelic
Composition
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background
involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh5tm1Rak mutation (1 available); any Msh5 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• oocyte numbers declined steadily with degeneration of ovaries

endocrine/exocrine glands
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
• 70% reduction in size

reproductive system
• oocyte numbers declined steadily with degeneration of ovaries
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
• 70% reduction in size
• abnormal chromosomal pairing (J:51921)
(J:62204)

growth/size/body
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts




Genotype
MGI:2663948
cx2
Allelic
Composition
Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background
involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (24 available)
Msh5tm1Rak mutation (1 available); any Msh5 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• abnormal chromosomal pairing





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/11/2018
MGI 6.12
The Jackson Laboratory