All Phenotypes Hoxa2<tm1Mrc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa2^tm1Mrc/Hoxa2^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:2177758
cx2	Hoxa1^tm1Mrc/Hoxa1^tm2Mrc Hoxa2^tm1Mrc/Hoxa2⁺	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:2170580
cx3	Hoxa1^tm2Mrc/Hoxa1^tm2Mrc Hoxa2^tm1Mrc/Hoxa2^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:2170585
cx4	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ	MGI:3043810
cx5	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3043811

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth of dehydration

behavior/neurological

abnormal suckling behavior ( J:58093 )

• unable to suckle

craniofacial

abnormal cranium morphology ( J:58093 )

• duplications of some cranial elements such as the pterygoid process and the squamosal

abnormal basioccipital bone morphology ( J:58093 )

• reduced ossification

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

cleft secondary palate ( J:58093 )

abnormal tongue muscle morphology ( J:58093 )

• tubotympanic cavity of unusual shape which interferes with styloglossus development

• hyoid musculature with abnormal insertions and sometimes abnormal origins as well

• defective insertions of muscles in the tongue (genioglossus unaffected)

abnormal styloglossus muscle morphology ( J:58093 )

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

skeleton

abnormal cranium morphology ( J:58093 )

• duplications of some cranial elements such as the pterygoid process and the squamosal

abnormal basioccipital bone morphology ( J:58093 )

• reduced ossification

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

muscle

abnormal tongue muscle morphology ( J:58093 )

• hyoid musculature with abnormal insertions and sometimes abnormal origins as well

• defective insertions of muscles in the tongue (genioglossus unaffected)

• tubotympanic cavity of unusual shape which interferes with styloglossus development

abnormal styloglossus muscle morphology ( J:58093 )

digestive/alimentary system

cleft secondary palate ( J:58093 )

abnormal tongue muscle morphology ( J:58093 )

• hyoid musculature with abnormal insertions and sometimes abnormal origins as well

• defective insertions of muscles in the tongue (genioglossus unaffected)

• tubotympanic cavity of unusual shape which interferes with styloglossus development

abnormal styloglossus muscle morphology ( J:58093 )

growth/size/body

cleft secondary palate ( J:58093 )

abnormal tongue muscle morphology ( J:58093 )

• hyoid musculature with abnormal insertions and sometimes abnormal origins as well

• defective insertions of muscles in the tongue (genioglossus unaffected)

• tubotympanic cavity of unusual shape which interferes with styloglossus development

abnormal styloglossus muscle morphology ( J:58093 )

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

Allelic Composition	Hoxa1^tm1Mrc/Hoxa1^tm2Mrc Hoxa2^tm1Mrc/Hoxa2⁺
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm1Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa1^tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2^tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth

craniofacial

abnormal cranium morphology ( J:58093 )

abnormal basioccipital bone morphology ( J:58093 )

• slight restructuring and reduced ossification

absent stapes ( J:58093 )

• absence of the stapes in many cases

small middle ear ossicles ( J:58093 )

• reduced middle ear apparatus

small ears ( J:58093 )

• reduced pinna of ear

hearing/vestibular/ear

absent stapes ( J:58093 )

• absence of the stapes in many cases

small middle ear ossicles ( J:58093 )

• reduced middle ear apparatus

small ears ( J:58093 )

• reduced pinna of ear

respiratory system

respiratory failure ( J:58093 )

• never initiate normal breathing patterns resulting in rapid death

skeleton

abnormal cranium morphology ( J:58093 )

abnormal basioccipital bone morphology ( J:58093 )

• slight restructuring and reduced ossification

absent stapes ( J:58093 )

• absence of the stapes in many cases

small middle ear ossicles ( J:58093 )

• reduced middle ear apparatus

growth/size/body

small ears ( J:58093 )

• reduced pinna of ear

Allelic Composition	Hoxa1^tm2Mrc/Hoxa1^tm2Mrc Hoxa2^tm1Mrc/Hoxa2^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm2Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa2^tm1Mrc mutation (0 available); any Hoxa2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

skeleton

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

nervous system

abnormal hindbrain morphology ( J:58093 )

• extensive hindbrain defects affecting breathing

craniofacial

abnormal middle ear ossicle morphology ( J:58093 )

• severe patterning defects in the middle ear and associated skeleton

small middle ear ossicles ( J:58093 )

• reduced size of middle ear elements

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

growth/size/body

absent outer ear ( J:58093 )

• pinna of ear almost entirely absent

Allelic Composition	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:58093 )

• die shortly after birth of dehydration

behavior/neurological

abnormal suckling behavior ( J:58093 )

• unable to suckle

craniofacial

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

digestive/alimentary system

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

growth/size/body

cleft secondary palate ( J:58093 )

• extent of cleft secondary palate not as great with decreased functional Hoxa1

Allelic Composition	Hoxa1^tm2Mrc/Hoxa1⁺ Hoxa2^tm1Mrc/Hoxa2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:58093 )

• viable and fertile

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