Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Pas mutation
(1 available);
any
Myf5 mutation
(17 available)
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muscle
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• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips
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• at E10 early myotome is missing
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• dorsal muscles are absent
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cellular
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• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Pas mutation
(1 available);
any
Myf5 mutation
(17 available)
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muscle
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• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice
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• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice
• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice
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embryo
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• at E11.5, somatic muscle progenitor cells exhibit a temporary pause in development but do not apoptose
• however, somite fate is rescued thereafter by Myod1 expression
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vision/eye
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• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice
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• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice
• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice
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mortality/aging
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• double homozygous mutants display postnatal lethality
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muscle
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• no skeletal myogenesis is seen at any developmental stage
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• mutants lack skeletal muscle throughout the body including the head
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Analysis Tools