• age of onset E9.5

• reported at 15 months of age

• Background Sensitivity: note that the tumor expression pattern is influenced by genetic background; authors note fewer large renal cystadenomas in outbred Black Swiss background and more angiosarcomas in 129S4/SvJae chimeric mice

• 50% incidence; causes fatal bleeding in 10% of these cases

• 32% incidence

• 100% incidence

• less than 10% incidence

• less than 10% incidence

• mice exhibit normal motor skills, exploratory behavior, anxiety and social approach behavior (J:138621)

• following contextual conditioning, mice exhibit reduced freezing compared to wild-type mice

• however, treatment with rapamycin re-establishes normal contextual conditioning

• in a hippocampus-dependent version of the Morris water maze test, spatial learning is impaired compared to in wild-type mice

• however, spatial learning in a hippocampus-independent water maze is normal and treatment with rapamycin re-establishes normal spatial learning

• mice exhibit more across-phase errors compared to in wild-type mice in a hippocampus-dependent win-shift version of the eight-arm radial maze

• mice exhibit normal basal synaptic transmission, paired-pulse facilitation and early-phase long term potentiation (J:138621)

• mice exhibit lowered late-phase threshold for long term potentiation compared to in wild-type mice

• however, treatment with rapamycin re-establishes normal late-phase long term potentiation