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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vhltm1Wml
targeted mutation 1, W Marston Linehan
MGI:1857702
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Vhltm1Wml/Vhltm1Wml involves: 129S4/SvJae * C57BL/6 MGI:2176441
ht2
Vhltm1Wml/Vhl+ involves: 129S4/SvJae * C57BL/6 MGI:5766045


Genotype
MGI:2176441
hm1
Allelic
Composition
Vhltm1Wml/Vhltm1Wml
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1Wml mutation (0 available); any Vhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Placental histopathology of normal and Vhltm1Wml/Vhltm1Wml embryos

mortality/aging
• death between E10.5 and E12.5, likely due to abnormal placental development

embryo
• failed embryonic vasculogenesis, with hemorrhage evident by E11.5 to E12.5
• lacked embryonic endothelium and blood vessels
• appeared normal until E9.5, but did not progress developmentally
• evident between E9.5 and E10.5

cardiovascular system
• failed embryonic vasculogenesis, with hemorrhage evident by E11.5 to E12.5
• lacked embryonic endothelium and blood vessels
• hemorrhagic placenta

Mouse Models of Human Disease
OMIM ID Ref(s)
Von Hippel-Lindau Syndrome; VHL 193300 J:42846 , J:88492




Genotype
MGI:5766045
ht2
Allelic
Composition
Vhltm1Wml/Vhl+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vhltm1Wml mutation (0 available); any Vhl mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• increased incidence of vascular neoplasms in the liver, uterus, ovary, spleen and heart in response to streptozotocin, compared to controls
• highest incidence and number found in liver
• lesions seen: angiectasia, hemangisarcoma, hemangioma
• no increase in renal lesions in response to streptozotocin, compared to controls

neoplasm
• increased incidence of vascular neoplasms in the liver, uterus, ovary, spleen and heart in response to streptozotocin, compared to controls
• highest incidence and number found in liver
• lesions seen: angiectasia, hemangisarcoma, hemangioma
• no increase in renal lesions in response to streptozotocin, compared to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory