About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ighmbp2nmd-2J
neuromuscular degeneration 2 Jackson
MGI:1857648
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ighmbp2nmd-2J/Ighmbp2nmd-2J B6.BKS-Ighmbp2nmd-2J/J MGI:3603515
hm2
Ighmbp2nmd-2J/Ighmbp2nmd-2J BKS.Cg Dock7m +/+ Leprdb-Ighmbp2nmd-2J MGI:3603467
cx3
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3765069
cx4
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)45Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3785080
cx5
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)108Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3785081
cx6
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
Tg(Ttn-Ighmbp2)108Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3785245
cx7
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)90Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3785251
cx8
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
Tg(Ttn-Ighmbp2)45Cx/?
involves: C57BL/6J * C57BLKS/J MGI:3785263
cx9
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J MGI:3603516
cx10
Cmn1CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J MGI:3612512
cx11
Cmn2CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J MGI:3612513
cx12
Cmn3CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J MGI:3612514
cx13
Cmn3C57BL/6J/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J MGI:3612515


Genotype
MGI:3603515
hm1
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic
Background
B6.BKS-Ighmbp2nmd-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 62 days for males and 76 days for females (J:90418)
• maximum life span is 138 days for females (J:90418)
• at 62 days for males and 76 days for females (J:90418)
• maximum life span is 138 days for females (J:90418)

cardiovascular system
• few desmosomes (J:90418)
• few desmosomes (J:90418)
• attenuated (J:90418)
• attenuated (J:90418)
• degenerating and apoptotic (J:90418)
• nuclear blebbing (J:90418)
• degenerating and apoptotic (J:90418)
• nuclear blebbing (J:90418)
• secondary valvular insufficiency (J:90418)
• secondary valvular insufficiency (J:90418)
• as early as 4-6 weeks of age (J:90418)
• pale, flaccid, enlarged hearts with one or more thrombi (J:90418)
• as early as 4-6 weeks of age (J:90418)
• pale, flaccid, enlarged hearts with one or more thrombi (J:90418)
• prolonged P-R interval (J:90418)
• prolonged P-R interval (J:90418)
• attenuated, sometimes split (J:90418)
• attenuated, sometimes split (J:90418)
• prolonged and attenuated R waves (J:90418)
• prolonged and attenuated R waves (J:90418)
• decreased lower end systolic blood pressure (J:90418)
• decreased lower end systolic blood pressure (J:90418)

nervous system
• frequently show indications of secondary myelin degeneration (J:92862)
• sometimes lacking axons (J:92862)
• frequently show indications of secondary myelin degeneration (J:92862)
• sometimes lacking axons (J:92862)
• axon numbers in quadriceps nerves significantly decrease with age from 3 weeks on, 40% reduction by 12-14 weeks (J:92862)
• axon numbers in quadriceps nerves significantly decrease with age from 3 weeks on, 40% reduction by 12-14 weeks (J:92862)
• significant neuronal loss by 7 weeks in all lumbar ventral roots examined (J:90418)
• 56% of L4 motor axons lost (J:90418)
• numerous dystrophic axons in ventral roots (J:90418)
• most losses are of large axons (J:90418)
• 40% loss of small caliber axons (J:90418)
• significant neuronal loss by 7 weeks in all lumbar ventral roots examined (J:90418)
• 56% of L4 motor axons lost (J:90418)
• numerous dystrophic axons in ventral roots (J:90418)
• most losses are of large axons (J:90418)
• 40% loss of small caliber axons (J:90418)
• vacuolation occurs during the course of myelination or after myelination (J:92862)
• abnormal cytoskeletons (J:92862)
• process of myelination normal (J:92862)
• vacuolation occurs during the course of myelination or after myelination (J:92862)
• abnormal cytoskeletons (J:92862)
• process of myelination normal (J:92862)
• denervation of motor endplates increases dramatically as motor neuron degeneration progresses (J:92862)
• denervation of motor endplates increases dramatically as motor neuron degeneration progresses (J:92862)

muscle
• few desmosomes (J:90418)
• few desmosomes (J:90418)
• attenuated (J:90418)
• attenuated (J:90418)
• degenerating and apoptotic (J:90418)
• nuclear blebbing (J:90418)
• degenerating and apoptotic (J:90418)
• nuclear blebbing (J:90418)
• as early as 4-6 weeks of age (J:90418)
• pale, flaccid, enlarged hearts with one or more thrombi (J:90418)
• as early as 4-6 weeks of age (J:90418)
• pale, flaccid, enlarged hearts with one or more thrombi (J:90418)
• severe muscle wasting and hind limb contracture (J:90418)
• severe muscle wasting and hind limb contracture (J:90418)
• variable fiber size (J:90418)
• variable fiber size (J:90418)
• centralized nuclei in myocytes (J:90418)
• centralized nuclei in myocytes (J:90418)
• development of diaphragmatic muscle degeneration occurs late, around 8-14 weeks (J:92862)
• development of diaphragmatic muscle degeneration occurs late, around 8-14 weeks (J:92862)
• and fatty infiltration (J:90418)
• and fatty infiltration (J:90418)
• severe diffuse myocyte degeneration and regeneration (J:90418)
• severe diffuse myocyte degeneration and regeneration (J:90418)

behavior/neurological
• much shorter latency to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top (J:90418)
• much shorter latency to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top much shorter latence to fall when suspended from a wire cage top (J:90418)

respiratory system
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)
• reduced breathing rate (bradypnea) (J:90418)
• reduced breathing rate (bradypnea) (J:90418)

growth/size/body

homeostasis/metabolism
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)




Genotype
MGI:3603467
hm2
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Genetic
Background
BKS.Cg Dock7m +/+ Leprdb-Ighmbp2nmd-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death usually by 3.5 weeks although survival for several months is possible if left with parents without normal siblings present (J:23584)
• death usually by 3.5 weeks although survival for several months is possible if left with parents without normal siblings present (J:23584)

behavior/neurological
• clench hindlimbs when picked up by the tail (J:23584)
• clench hindlimbs when picked up by the tail (J:23584)
• unable to grasp cage cover when set upon it (J:23584)
• unable to grasp cage cover when set upon it (J:23584)
• rely on forelimbs to crawl forward, but balance and righting responses are normal (J:23584)
• rely on forelimbs to crawl forward, but balance and righting responses are normal (J:23584)
• dorsally contracted hindlimbs cannot be extended to stand erect or assume full posture on four limbs (J:23584)
• dorsally contracted hindlimbs cannot be extended to stand erect or assume full posture on four limbs (J:23584)

muscle
• intermixture of very small muscle fibers with more normal fibers (J:23584)
• distal musculature of limbs more severely affected but focal areas of muscle degeneration proximally as well (J:23584)
• intermixture of very small muscle fibers with more normal fibers (J:23584)
• distal musculature of limbs more severely affected but focal areas of muscle degeneration proximally as well (J:23584)
• atrophic muscle fibers in the masseter (J:23584)
• atrophic muscle fibers in the masseter (J:23584)
• atrophic muscle fibers in the temporalis muscle (J:23584)
• atrophic muscle fibers in the temporalis muscle (J:23584)

nervous system
• affected alpha motor neurons with pale staining nuclei and perikarya (J:23584)
• mostly in lumbar region (J:23584)
• affected alpha motor neurons with pale staining nuclei and perikarya (J:23584)
• mostly in lumbar region (J:23584)




Genotype
MGI:3765069
cx3
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Eno2-Ighmbp2)17Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 49 days for males and 54 days for females (J:90418)
• maximum life span is 87 days for females (J:90418)
• at 49 days for males and 54 days for females (J:90418)
• maximum life span is 87 days for females (J:90418)

cardiovascular system
• grossly dilated hearts with one or more thrombi (J:90418)
• grossly dilated hearts with one or more thrombi (J:90418)
• prolonged P-R interval (J:90418)
• prolonged P-R interval (J:90418)
• sometimes split (J:90418)
• sometimes split (J:90418)
• prolonged (J:90418)
• prolonged (J:90418)

muscle
N
• grossly normal hind limb muscle phenotype (J:90418)
• grossly normal hind limb muscle phenotype (J:90418)
• grossly dilated hearts with one or more thrombi (J:90418)
• grossly dilated hearts with one or more thrombi (J:90418)
• mild myopathic changes including myocyte degeneration and regeneration with centralized nucleii (J:90418)
• mild myopathic changes including myocyte degeneration and regeneration with centralized nucleii (J:90418)

nervous system
N
• axon morphology and nerve root diameters are normal (J:90418)
• axon morphology and nerve root diameters are normal (J:90418)

respiratory system
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)
• reduced breathing rate (bradypnea) (J:90418)
• reduced breathing rate (bradypnea) (J:90418)

growth/size/body

homeostasis/metabolism
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)




Genotype
MGI:3785080
cx4
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)45Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Ttn-Ighmbp2)45Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lifespan is longer than that of nmd-2J mutants but shorter than that of the wild-type controls and falls partway between the two points (J:102748)
• lifespan is longer than that of nmd-2J mutants but shorter than that of the wild-type controls and falls partway between the two points (J:102748)

nervous system
• severe skeletal muscle neurogenic atrophy (J:102748)
• severe skeletal muscle neurogenic atrophy (J:102748)

muscle
• resulting from the spinal motor neuron degeneration (J:102748)
• resulting from the spinal motor neuron degeneration (J:102748)

behavior/neurological
• difficulty in mastication or deglutition (J:102748)
• difficulty in mastication or deglutition (J:102748)

cardiovascular system
N
• mean ventricular free-wall thickness is normal (J:102748)
• mean ventricular free-wall thickness is normal (J:102748)

digestive/alimentary system
• difficulty in mastication or deglutition (J:102748)
• difficulty in mastication or deglutition (J:102748)
• susceptible to mega-esophagus (J:102748)
• susceptible to mega-esophagus (J:102748)

growth/size/body
• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes (J:102748)
• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes (J:102748)




Genotype
MGI:3785081
cx5
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)108Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Ttn-Ighmbp2)108Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lifespan is longer than that of nmd-2J mutants but shorter than that of wild-type controls and falls partway between the two points (J:102748)
• lifespan is longer than that of nmd-2J mutants but shorter than that of wild-type controls and falls partway between the two points (J:102748)

nervous system
• severe skeletal muscle neurogenic atrophy (J:102748)
• severe skeletal muscle neurogenic atrophy (J:102748)

muscle
• resulting from the spinal motor neuron degeneration (J:102748)
• resulting from the spinal motor neuron degeneration (J:102748)

behavior/neurological
• difficulty in mastication or deglutition (J:102748)
• difficulty in mastication or deglutition (J:102748)

cardiovascular system
N
• mean ventricular free-wall thickness is normal (J:102748)
• mean ventricular free-wall thickness is normal (J:102748)

digestive/alimentary system
• difficulty in mastication or deglutition (J:102748)
• difficulty in mastication or deglutition (J:102748)
• susceptible to mega-esophagus (J:102748)
• susceptible to mega-esophagus (J:102748)

growth/size/body
• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes (J:102748)
• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes (J:102748)




Genotype
MGI:3785245
cx6
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
Tg(Ttn-Ighmbp2)108Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Eno2-Ighmbp2)17Cx mutation (1 available)
Tg(Ttn-Ighmbp2)108Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy (J:102748)
• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy (J:102748)




Genotype
MGI:3785251
cx7
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)90Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Eno2-Ighmbp2)90Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• phenotype is stated to be identical to that observed when Tg(Eno2-Ighmbp2)17Cx mice are used in this cross (GA Cox, personal communication) (J:90418)
• phenotype is stated to be identical to that observed when Tg(Eno2-Ighmbp2)17Cx mice are used in this cross (GA Cox, personal communication) (J:90418)

growth/size/body

cardiovascular system

muscle
N
(J:90418)
(J:90418)

respiratory system

nervous system
N
(J:90418)
(J:90418)

homeostasis/metabolism




Genotype
MGI:3785263
cx8
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
Tg(Ttn-Ighmbp2)45Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
Tg(Eno2-Ighmbp2)17Cx mutation (1 available)
Tg(Ttn-Ighmbp2)45Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy (J:102748)
• increased heart weight proportionally distributed throughout all 4 chambers, but aside from this the presence of both transgenes rescues nmd-2J homozygotes to a wild-type phenotype including no cardiomyopathy (J:102748)




Genotype
MGI:3603516
cx9
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
Genetic
Background
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
MnmC mutation (0 available); any Mnm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: survival to as long as 7 months of age, but less as the B6 component of the background increases (J:51890)
• Background Sensitivity: survival to as long as 7 months of age, but less as the B6 component of the background increases (J:51890)

cardiovascular system
• grossly dilated hearts with one or more thrombi (J:90418)
• grossly dilated hearts with one or more thrombi (J:90418)
• prolonged P-R interval (J:90418)
• prolonged P-R interval (J:90418)
• sometimes split (J:90418)
• sometimes split (J:90418)

nervous system
• fewer dying neurons (J:51890)
• fewer dying neurons (J:51890)
• modest reduction in lumbar ventral root diameter (J:90418)
• 26% of L4 motor axons lost (J:90418)
• occasional dystrophic axons in ventral roots (J:90418)
• 25% loss of small caliber axons (J:90418)
• modest reduction in lumbar ventral root diameter (J:90418)
• 26% of L4 motor axons lost (J:90418)
• occasional dystrophic axons in ventral roots (J:90418)
• 25% loss of small caliber axons (J:90418)

behavior/neurological
• shorter latence to fall when suspended from a wire cage top (J:90418)
• shorter latence to fall when suspended from a wire cage top (J:90418)

muscle
• grossly dilated hearts with one or more thrombi (J:90418)
• grossly dilated hearts with one or more thrombi (J:90418)
• moderate myopathic changes (J:90418)
• moderate myopathic changes (J:90418)
• milder muscle atrophy (J:51890)
• milder muscle atrophy (J:51890)

respiratory system
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)
• reduced breathing rate (bradypnea) (J:90418)
• reduced breathing rate (bradypnea) (J:90418)

growth/size/body

homeostasis/metabolism
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• 3-7 days prior to clearly evident clinical signs of heart disease, total plasma CK and cardiac-specific CK-MB levels in 5- to 9-week-old mice become significantly elevated (J:90418)
• consolidation of lungs (J:90418)
• consolidation of lungs (J:90418)




Genotype
MGI:3612512
cx10
Allelic
Composition
Cmn1CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
Genetic
Background
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn1CAST/Ei mutation (0 available); any Cmn1 mutation (0 available)
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
MnmC mutation (0 available); any Mnm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)

muscle
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)




Genotype
MGI:3612513
cx11
Allelic
Composition
Cmn2CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
Genetic
Background
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn2CAST/Ei mutation (0 available); any Cmn2 mutation (0 available)
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
MnmC mutation (0 available); any Mnm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)

muscle
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)
• resistance to dilated cardiomyopathy (J:102748)
• increased survival time (J:102748)




Genotype
MGI:3612514
cx12
Allelic
Composition
Cmn3CAST/Ei/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
Genetic
Background
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn3CAST/Ei mutation (0 available); any Cmn3 mutation (0 available)
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
MnmC mutation (0 available); any Mnm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• resistance to dilated cardiomyopathy in males (J:102748)
• increased survival time in males (J:102748)
• resistance to dilated cardiomyopathy in males (J:102748)
• increased survival time in males (J:102748)

muscle
• resistance to dilated cardiomyopathy in males (J:102748)
• increased survival time in males (J:102748)
• resistance to dilated cardiomyopathy in males (J:102748)
• increased survival time in males (J:102748)




Genotype
MGI:3612515
cx13
Allelic
Composition
Cmn3C57BL/6J/?
Ighmbp2nmd-2J/Ighmbp2nmd-2J
MnmC/MnmC
Genetic
Background
involves: C57BL/6J * C57BLKS/J * CAST/Ei * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cmn3C57BL/6J mutation (0 available); any Cmn3 mutation (0 available)
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (8 available)
MnmC mutation (0 available); any Mnm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• resistance to dilated cardiomyopathy in females (J:102748)
• increased survival time in females (J:102748)
• resistance to dilated cardiomyopathy in females (J:102748)
• increased survival time in females (J:102748)

muscle
• resistance to dilated cardiomyopathy in females (J:102748)
• increased survival time in females (J:102748)
• resistance to dilated cardiomyopathy in females (J:102748)
• increased survival time in females (J:102748)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory