About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map2k4tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:1857536
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map2k4tm1Pngr/Map2k4tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:2167066


Genotype
MGI:2167066
hm1
Allelic
Composition		 Map2k4tm1Pngr/Map2k4tm1Pngr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Pngr mutation (1 available); any Map2k4 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:51597 )
• embryos die between E10.5 and E12.5

hematopoietic system
anemia ( J:51597 )
• severe by E11.5
• normal vasculogenesis
• normal hematopoiesis

liver/biliary system
abnormal liver development ( J:51597 )
• primordial liver forms, but is severely disorganized and contained clusters of hematopoietic precursor and erythrocyte cells; becomes apoptotic




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory