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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map2k4tm1Pngr
targeted mutation 1, Josef M Penninger
MGI:1857536
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map2k4tm1Pngr/Map2k4tm1Pngr involves: 129P2/OlaHsd * C57BL/6 MGI:2167066


Genotype
MGI:2167066
hm1
Allelic
Composition
Map2k4tm1Pngr/Map2k4tm1Pngr
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Pngr mutation (1 available); any Map2k4 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die between E10.5 and E12.5

hematopoietic system
• severe by E11.5
• normal vasculogenesis
• normal hematopoiesis

liver/biliary system
• primordial liver forms, but is severely disorganized and contained clusters of hematopoietic precursor and erythrocyte cells; becomes apoptotic





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory