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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pomctm1Low
targeted mutation 1, Malcolm J Low
MGI:1857481
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pomctm1Low/Pomctm1Low B6.129S2-Pomctm1Low MGI:3814213
hm2
Pomctm1Low/Pomctm1Low B6.129S2-Pomctm1Low/J MGI:4833828
hm3
Pomctm1Low/Pomctm1Low involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 MGI:4833823
hm4
Pomctm1Low/Pomctm1Low involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4833833
hm5
Pomctm1Low/Pomctm1Low involves: 129S2/SvPas * C57BL/6 MGI:4833797
hm6
Pomctm1Low/Pomctm1Low involves: 129S2/SvPas * C57BL/6 * Swiss albino MGI:4833824
hm7
Pomctm1Low/Pomctm1Low involves: 129S2/SvPas * C57BL/6N MGI:4833779
ht8
Pomctm1Low/Pomc+ involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4833834
cx9
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/0
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833835
cx10
Pomctm1Low/Pomc+
Tg(Pomc)#Low/0
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833836
cx11
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/Tg(Pomc)#Low
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster MGI:4833837
cx12
Mc4rtm1Dhu/Mc4rtm1Dhu
Pomctm1Low/Pomctm1Low
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:4833825


Genotype
MGI:3814213
hm1
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
B6.129S2-Pomctm1Low
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants do not show reduced sensitivity to morphine seen in wild-type mice following partial sciatic nerve ligation (pSNL); sensitivity is similar to sham-ligated controls
• after 9 day, mice acquire ethanol self-administration unlike wild-type mice
• over time, mice increase their consumption of ethanol unlike wild-type mice
• after training with 5 mg/kg morphine, wild-type mice with pSNL spend less time in the drug-paired compartment than mutants with pSNL; morphine conditioned place preference is not different with or without pSNL in mutants
• mice exhibit increased rate of response when nose-pokes resulted in alcohol administration unlike similarly treated wild-type mice
• male mice exhibit increased food intake compared with wild-type mice
• male mice treated with neuropeptide Y (NPY) exhibit a greater increase in food intake compared with similarly treated wild-type mice

adipose tissue
N
• mice exhibit normal intrascapular brown fat weight
• total body fat amount is increased 50% in male mice compared to in wild-type mice
• however, female mice exhibit normal fat content
• in male mice
• 2-fold in male mice
• inguinal fat pad weight is increased 2-fold in male mice compared to in wild-type mice
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype
• 2-fold in male mice
• retroperitoneal fat pad weight is increased 2-fold in male mice compared to in wild-type mice
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype

homeostasis/metabolism
N
• male mice exhibit normal basal metabolic rate (oxygen consumption and respiratory quotient) and T4 serum levels
• in obese male mice
• mice fed a high fat diet exhibit an increase in urinary adrenaline levels compared to in similarly treated wild-type mice
• in obese male mice
• mice treated with neuropeptide Y (NPY) exhibit a greater increase in food intake than similarly treated wild-type mice
• naloxone-treated mice exhibit a greater decrease in food intake than similarly treated wild-type mice

growth/size/body
• starting at 4 weeks and continuing through adulthood, male mice exhibit an increase in body weight compared with wild-type mice (J:115712)
• between 4 and 8 weeks, female mice exhibit an increase in body weight compared with wild-type mice (J:115712)
• however, over-expression of the gene in the pituitary partially rescues the phenotype while over-expression in the central nervous system completely rescues the phenotype (J:115712)
• in male mice

cardiovascular system
• after two weeks on a high salt diet

nervous system
• mice fed a high fat diet exhibit an increase in urinary adrenaline levels compared to in similarly treated wild-type mice
• mice fed a high salt diet exhibit a greater increase in Fos-Li neurons in the median preoptic nucleus compared with similarly treated wild-type mice

renal/urinary system
• mice fed a high fat diet exhibit an increase in urinary adrenaline levels compared to in similarly treated wild-type mice




Genotype
MGI:4833828
hm2
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
B6.129S2-Pomctm1Low/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal sleep patterns
• while the number of clinches is normal, mice transferred to the cage of an aggressive dominant conspecific exhibit increased signs of aggression compared with similarly treated wild-type mice that exhibit freezing or fleeing

homeostasis/metabolism
• slightly after 1 hour of social conflict

growth/size/body




Genotype
MGI:4833823
hm3
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in male mice




Genotype
MGI:4833833
hm4
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• corticotroph and melanotroph adenomas

mortality/aging
• 60% of mice die by P1
• however, mice that survive P1 exhibit normal survival

homeostasis/metabolism
• in the pituitary and hypothalamus

endocrine/exocrine glands
• the zona fasciculata is decreased in height compared to in wild-type mice
• the columnar cells arrangement is replaced by disorganized, densely packed cells with scant cytoplasm unlike in wild-type mice
• corticotroph and melanotroph adenomas

neoplasm
• corticotroph and melanotroph adenomas




Genotype
MGI:4833797
hm5
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to LPS or Con A treatment
• in LPS-treated splenocytes
• in LPS-treated splenocytes

homeostasis/metabolism
• LPS-treated mice do not exhibit as much of an increased in circulating corticosterone levels as in similarly treated wild-type mice
• LPS-treated mice do not exhibit as much of an increased in circulating adrenocorticotropin levels as in similarly treated wild-type mice

hematopoietic system
• in response to LPS or Con A treatment

cellular
• in response to LPS or Con A treatment




Genotype
MGI:4833824
hm6
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * Swiss albino
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• in male mice




Genotype
MGI:4833779
hm7
Allelic
Composition
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit decreased mild swim-stress analgesia (measured by abdominal constriction) compared with similarly treated wild-type mice
• naloxone-treated mice exhibit an increase in mild swim-stress analgesia (measured by abdominal constriction) while similarly treated wild-type mice exhibit a decreased in mild swim-stress analgesia
• mice lack opioid stress-induced analgesia compared with similarly treated wild-type mice
• however, un-stressed mice exhibit normal analgesic response to morphine
• following a swim stress at 10 degrees Celsius, mice exhibit increased analgesia (measured by hotplate assay) compared with wild-type mice regardless of naloxone treatment
• mice exhibit decreased mild swim-stress analgesia (measured by abdominal constriction) compared with similarly treated wild-type mice
• naloxone-treated mice exhibit an increase in mild swim-stress analgesia (measured by abdominal constriction) while similarly treated wild-type mice exhibit a decreased in mild swim-stress analgesia

growth/size/body
• after the onset of puberty

integument
• following a swim stress at 10 degrees Celsius, mice exhibit increased analgesia (measured by hotplate assay) compared with wild-type mice regardless of naloxone treatment
• mice exhibit decreased mild swim-stress analgesia (measured by abdominal constriction) compared with similarly treated wild-type mice
• naloxone-treated mice exhibit an increase in mild swim-stress analgesia (measured by abdominal constriction) while similarly treated wild-type mice exhibit a decreased in mild swim-stress analgesia




Genotype
MGI:4833834
ht8
Allelic
Composition
Pomctm1Low/Pomc+
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• melanotroph adenomas

endocrine/exocrine glands
• melanotroph adenomas

neoplasm
• melanotroph adenomas




Genotype
MGI:4833835
cx9
Allelic
Composition
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
Tg(Pomc)#Low mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• melanotroph adenomas

mortality/aging
N
• mice exhibit normal survival perinatally

homeostasis/metabolism
• male mice exhibit an abnormal corticosterone secretion pattern with exaggerated nadir and peak levels compared with wild-type mice
• however, corticosterone secretion pattern in female mice is normal
• in the hypothalamus
• however, expression is restored in the pituitary
• in male and female mice under acute restrain stress

endocrine/exocrine glands
• the zona fasciculata is hypertrophic with increased volume of eosinophilic cytoplasm per cell and decreased numbers of cells per high-power field compared to in wild-type mice
• greater in male than female mice
• melanotroph adenomas

growth/size/body

neoplasm
• melanotroph adenomas




Genotype
MGI:4833836
cx10
Allelic
Composition
Pomctm1Low/Pomc+
Tg(Pomc)#Low/0
Genetic
Background
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
Tg(Pomc)#Low mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• melanotroph adenomas

endocrine/exocrine glands
• melanotroph adenomas

neoplasm
• melanotroph adenomas




Genotype
MGI:4833837
cx11
Allelic
Composition
Pomctm1Low/Pomctm1Low
Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic
Background
involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
Tg(Pomc)#Low mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• compared with Tg(Pomc)#Low homozygotes

homeostasis/metabolism
• compared with Tg(Pomc)#Low homozygotes




Genotype
MGI:4833825
cx12
Allelic
Composition
Mc4rtm1Dhu/Mc4rtm1Dhu
Pomctm1Low/Pomctm1Low
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1Dhu mutation (0 available); any Mc4r mutation (18 available)
Pomctm1Low mutation (1 available); any Pomc mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• compared with either single homozygote

growth/size/body
• compared with either single homozygote





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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory