All Phenotypes Ccl3<tm1Unc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccl3^tm1Unc
targeted mutation 1, University of North Carolina
MGI:1857243

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl3^tm1Unc/Ccl3^tm1Unc	B6.129P2-Ccl3^tm1Unc/J	MGI:3524873
hm2	Ccl3^tm1Unc/Ccl3^tm1Unc	involves: 129P2/OlaHsd	MGI:2660695
hm3	Ccl3^tm1Unc/Ccl3^tm1Unc	involves: 129P2/OlaHsd * C57BL/6	MGI:4418575
cx4	Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3579804
cx5	Ccl3^tm1Unc/Ccl3⁺ Hexb^tm1Rlp/Hexb^tm1Rlp	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:3579805

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	B6.129P2-Ccl3^tm1Unc/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

alcohol aversion ( J:102583 )

decreased alcohol consumption ( J:102583 )

abnormal conditioned taste aversion behavior ( J:102583 )

• male mice consume more saccharin in an ethanol-induced conditioned taste aversion test compared with similarly treated wild-type mice

• mice exhibit a stronger response to ethanol in an ethanol-induced conditioned taste aversion test compared with similarly treated wild-type mice

• however, saccharin consumption in female mice is normal

increased fluid intake ( J:102583 )

• male mice exhibit increased drinking of an ethanol or quinine solution compared with similarly treated wild-type mice

impaired righting response ( J:102583 )

• mice exhibit longer duration of ethanol-induced loss of righting response compared with similarly treated wild-type mice

immune system

decreased neutrophil cell number ( J:94599 )

• 13-28% decrease in the number of infiltrating neutrophils in the skin at 4 and 8 hours after immune complex challenge compared to wild-type

decreased susceptibility to type III hypersensitivity reaction ( J:94599 )

• 20% reduction in edema, but no difference in hemorrhage, when cutaneous reverse passive Arthus reaction was induced compared to wild-type

hematopoietic system

decreased neutrophil cell number ( J:94599 )

• 13-28% decrease in the number of infiltrating neutrophils in the skin at 4 and 8 hours after immune complex challenge compared to wild-type

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

decreased susceptibility to bacterial infection ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

abnormal susceptibility to Orthomyxoviridae infection ( J:107677 )

• influenza viral titers are higher in mutants at day 3, 6 and 7 post infection compared to wild-type, however by day 21 post infection, no virus is detected, indicating a delay in T cell-dependent viral clearance

decreased susceptibility to Orthomyxoviridae infection ( J:107677 )

• reduced pneumonitis after infection with influenza virus

decreased susceptibility to Picornaviridae infection ( J:28704 )

• resistance to Coxsackie virus-induced myocarditis

digestive/alimentary system

cecum inflammation ( J:107677 )

• mice treated with toxin A exhibit less severe enteritis (reduced fluid accumulation, neutrophil infiltration, and epithelial damage) compared with wild-type mice

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:70862 )

N	• mice exhibit normal wound healing

nervous system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

abnormal astrocyte physiology ( J:153059 )

• significant reduction in activated astrocytes in the hippocampus 6 hours after injection of beta amyloid 1-40

behavior/neurological

abnormal spatial learning ( J:153059 )

• improved learning performance in a Morris water maze after injection of beta amyloid 1-40 relative to controls

abnormal long-term spatial reference memory ( J:153059 )

• in a Morris water maze

immune system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

hematopoietic system

decreased microglial cell activation ( J:153059 )

• significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40

Allelic Composition	Ccl3^tm1Unc/Ccl3^tm1Unc Hexb^tm1Rlp/Hexb^tm1Rlp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl3^tm1Unc mutation (1 available); any Ccl3 mutation (13 available)
Hexb^tm1Rlp mutation (1 available); any Hexb mutation (91 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hexb^tm1Rlp/Hexb^tm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice

mortality/aging

premature death ( J:90687 )

• life span of approximately 156 days (maximum 175 days)

behavior/neurological

abnormal motor coordination/balance ( J:90687 )

• improved performance on a rotarod compared to mice homozygous for the Hexb allele alone

abnormal righting response ( J:90687 )

• improved relative to mice homozygous for the Hexb allele alone

growth/size/body

growth/size/body region phenotype ( J:90687 )

N	• maintained body weight through 19 weeks of age

immune system

abnormal tumor necrosis factor level ( J:90687 )

• 87% reduction of TNF alpha in the spinal cord relative to levels seen in mice homozygous only for Hexb^tm1Rlb

CNS inflammation ( J:90687 )

• fewer cells infiltrating the CNS of 4 month old mice

cellular

cellular phenotype ( J:90687 )

N	• near absence of apoptosis in the central nervous system

nervous system

CNS inflammation ( J:90687 )

• fewer cells infiltrating the CNS of 4 month old mice

homeostasis/metabolism

abnormal tumor necrosis factor level ( J:90687 )

• 87% reduction of TNF alpha in the spinal cord relative to levels seen in mice homozygous only for Hexb^tm1Rlb

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sandhoff disease		DOID:3323	OMIM:268800	J:90687

Allelic Composition	Ccl3^tm1Unc/Ccl3⁺ Hexb^tm1Rlp/Hexb^tm1Rlp
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:90687 )

• life span of approximately 138 day

behavior/neurological

abnormal motor coordination/balance ( J:90687 )

• improved performance on a rotarod compared to mice homozygous for the Hexb allele alone

abnormal righting response ( J:90687 )

• improved relative to mice homozygous for the Hexb allele alone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sandhoff disease		DOID:3323	OMIM:268800	J:90687

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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