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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ntf5tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:1857233
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ntf5tm1Jae/Ntf5tm1Jae involves: 129S4/SvJae MGI:2175182
cx2
Bdnftm1Jae/Bdnftm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
involves: 129S4/SvJae MGI:3761003
cx3
Ngfrtm1Jae/Ngfrtm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
involves: 129S4/SvJae MGI:3770686


Genotype
MGI:2175182
hm1
Allelic
Composition
Ntf5tm1Jae/Ntf5tm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Jae mutation (1 available); any Ntf5 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice
• significant loss of all sensory neuron types in the nodose-petrosal, geniculate and L4 dorsal root ganglion in homozygous mice
• no difference in the number of facial motor neurons or superior cervical ganglion neurons is seen compared to controls
• no difference in the number of midbrain dopaminergic neurons is seen compared to controls
• approximately half of the neurons are lost from the geniculate ganglion at E18.5
• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5
• greater than half of the neurons are lost from the nodose-petrosal ganglion at E18.5
• approximately 20% of the neurons are lost from the vestibular ganglion
• approximately 15% of the neurons are lost from the L4 DRG at two months of age

integument
• retarded catagen progression; follicles are still in early or middle catagen at time points when controls are in late catagen
• skin thicker than in controls

cellular
• at E12 and E14, neuron apoptosis is reduced 74% and 65%, respectively, compared to in wild-type mice




Genotype
MGI:3761003
cx2
Allelic
Composition
Bdnftm1Jae/Bdnftm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Jae mutation (2 available); any Bdnf mutation (38 available)
Ntf5tm1Jae mutation (1 available); any Ntf5 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygous mice die within 48 hours of birth, with only a few surviving up to 10 days of age

growth/size/body
• homozygous mice are the same size as controls at birth, but fail to grow thereafter

nervous system
• significant loss of all sensory neuron types in the trigeminal, vestibular, nodose-petrosal and geniculate ganglia in homozygous mice
• no statistical difference in the number of facial motor neurons is seen compared to controls
• approximately 95% of the neurons are lost from the geniculate ganglion at E18.5
• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5
• approximately 30% of the neurons are lost from the trigeminal ganglion at E18.5
• approximately 90% of the neurons are lost from the nodose-petrosal ganglion at E18.5
• approximately 80% of the neurons are lost from the vestibular ganglion at E18.5
• mice exhibit a 25% loss of trigeminal neurons at birth

behavior/neurological




Genotype
MGI:3770686
cx3
Allelic
Composition
Ngfrtm1Jae/Ngfrtm1Jae
Ntf5tm1Jae/Ntf5tm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngfrtm1Jae mutation (2 available); any Ngfr mutation (30 available)
Ntf5tm1Jae mutation (1 available); any Ntf5 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice

cellular
• at E12 and E14, neuron apoptosis is reduced 79% and 63%, respectively, compared to in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory