Phenotypes associated with this allele
Allelic Composition |
Myf5tm1Jae/Myf5tm1Jae
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Genetic Background |
either: 129-Myf5tm1Jae or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
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mortality/aging
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• die immediately after birth
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respiratory system
skeleton
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• ribs do not attach to the sternum due to their truncation
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• the sternum is completely ossified without sternebral segmentation
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• absence of the major distal part of the ribs; the cranial rib stumps on both sides of the vertebral column end in dilated enlarged structures
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embryo
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• appearance of myotomal cells in early somites is delayed by several days
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muscle
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• organization of muscles in the anterior thoracic wall is disorganized, probably due to lack of ribs
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• muscle-specific marker analysis indicates a delay in the development of the myotome
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
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skeleton
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• no contacts with the sternum are made because the ribs are short
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• sternum is completely ossified
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• mutants lack the distal parts of the ribs; ribs are shorter than in Myf6 homozygotes
(J:31636)
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muscle
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• no myotomes are detected at E10.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
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skeleton
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• animals show extensive vertebral arch fusions compared to wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
Myf5tm3.1Thbr mutation
(0 available);
any
Myf5 mutation
(17 available)
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skeleton
N |
• skeleton, including ribs is normal
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Allelic Composition |
Myf5tm1Jae/Myf5+ Myf6tm1Wb/Myf6+
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Genetic Background |
involves: 129S1/Sv * 129S4/SvJae |
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mortality/aging
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• double heterozygous mice in which the Myf5 and Myf6 alleles are on different chromosomes show severely reduced expression of Myf5 and die at birth due to respiratory distress
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respiratory system
skeleton
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• sternum shows irregular ossification of sternebrae
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• none of the first seven ribs are attached to the sternum
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• fusion of adjacent ribs
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• short ribs; ribs are shorter than in wild-type or Myf6 homozygotes but longer than the stubs of Myf5 homozygotes
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muscle
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• myotomes are disorganized at E10.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
Myf6tm1Thbr mutation
(0 available);
any
Myf6 mutation
(19 available)
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mortality/aging
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• double heterozygous mice that carry the Myf5 and Myf6 alleles on different chromosomes and express drastically reduced levels of Myf5 mRNA do not survive to weaning and when delivered by cesarean section at E18.5, the pups die within a few minutes after delivery
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skeleton
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• mutants lack the distal parts of the ribs
• the average rib length is between that of Myf6 and Myf5 homozygotes
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Allelic Composition |
Myf5tm1Jae/Myf5+ Myf6tm1Eno/Myf6+
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Genetic Background |
involves: 129S4/SvJae * 129S7/SvEvBrd |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
Myf6tm1Eno mutation
(0 available);
any
Myf6 mutation
(19 available)
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mortality/aging
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• 63% of double heterozygous mice, in which the Myf5 and Myf6 alleles are on different chromosomes and show severely reduced expression of Myf5, die immediately after birth; the rest survive
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skeleton
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• attachment failure of at least one rib to the sternum is seen in most mutants, although the identity of the affected rib(s) and the number of ribs affected varies
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muscle
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• number of myocytes in the myotomes is reduced at E10.5 and the conformation of the myotome is abnormal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
Myod1tm1.1Glh mutation
(0 available);
any
Myod1 mutation
(23 available)
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muscle
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• trunk musculature is disorganized compared to in wild-type mice
• expression of Myod1 is delayed at E10.5 compared to in wild-type mice
• however, the Pax3-mediated recovery of Myod1 is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation
(1 available);
any
Myf5 mutation
(17 available)
Myod1tm1.1Glh mutation
(0 available);
any
Myod1 mutation
(23 available)
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muscle
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• trunk musculature is disorganized compared to in wild-type mice
• expression of Myod1 is delayed at E10.5 compared to in wild-type mice
• however, the Pax3-mediated recovery of Myod1 is normal
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