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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fn1tm1Hyn
targeted mutation 1, Richard Hynes
MGI:1857170
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fn1tm1Hyn/Fn1tm1Hyn involves: 129S2/SvPas * C57BL/6J MGI:2168531


Genotype
MGI:2168531
hm1
Allelic
Composition
Fn1tm1Hyn/Fn1tm1Hyn
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fn1tm1Hyn mutation (5 available); any Fn1 mutation (80 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes develop severe embryonic abnormalities from E8.0 onwards and undergo degeneration during E10 and E11

cardiovascular system
• at E8.5, severely affected embryos show absence of dorsal aortae while less severely affected embryos exhibit distended dorsal aortae containing only a few blood cells
• at E8.5, homozygotes display defective vasculogenesis in the yolk sac
• mutant embryonic vessels appear variable and deformed while extraembryonic vasculature is also defective
• at E8.5, blood vessels are detected in the exocoelomic cavity rather than in the yolk sac
• at E8.5, 13 of 20 mutant embryos have a visible primitive heart whereas the remaining seven do not
• in severely affected embryos, heart primordia fail to fuse and are positioned laterally
• at E8.5, cardiac jelly is deficient
• at E8.5, the mutant endocardium is either indistinguishable from the thickened myocardium or absent
• at E8.5, homozygotes display a thickened myocardium

embryo
• at E8.5, none of the mutant embryos have initiated turning
• at E8.0, homozygotes exhibit a deficit in the trunk and headfold mesoderm
• by E8.5, mutant headfolds appear small and misshapen, with a deficit in underlying mesoderm and many pyknotic cells
• at E8.0, homozygotes display a shortened anterior-posterior axis
• starting at E8.0, homozygotes appear developmentally retarded and abnormal
• at E7.5, mutant embryos appear relatively normal, though slightly smaller than wild-type embryos
• by E8.5, lateral mesoderm flanking the neural tube is reduced
• at E8.0, homozygotes display multiple bends and distortions in the neural ectoderm
• at E8.5, homozygotes display a kinked neural tube
• at E8.5, homozygotes lack an organized notochord; instead, the endodermal lining of the future midgut is juxtaposed to the neural tube
• at E8.5, mutant embryos lack somites whereas wild-type embryos contain 8 to 12 pairs of somites; however, condensations of cells suggestive of incipient somites are detected in 3 of 20 mutants
• at E8.5, blood vessels are detected in the exocoelomic cavity rather than in the yolk sac
• at E7.5, mutant embryos possess three germ layers and normal extraembryonic membranes except for a concave amnion
• at E8.0, the mutant amnion is undersized and closely apposed to the embryo, displaying a pressure deficit in the amniotic cavity
• at E8.5, the mesodermal and endodermal layers of the mutant yolk sac appear to split apart
• at E8.5, the allantois has yet not fused with the chorion

nervous system
• at E8.0, homozygotes display multiple bends and distortions in the neural ectoderm
• at E8.5, homozygotes display a kinked neural tube

growth/size/body
• starting at E8.0, homozygotes appear developmentally retarded and abnormal
• at E7.5, mutant embryos appear relatively normal, though slightly smaller than wild-type embryos





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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory