All Phenotypes Rd3<rd3> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rd3^rd3
retinal degeneration 3
MGI:1857014

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rd3^rd3/Rd3^rd3	RBF/DnJ-Rd3^rd3	MGI:3715440
cx2	Mrdq1^C57BL/6/Mrdq1^C57BL/6 Rd3^rd3/Rd3^rd3	involves: BALB/cByJ * C57BL/6	MGI:3803150
cx3	Mrdq2^BALB/cByJ/Mrdq2^BALB/cByJ Rd3^rd3/Rd3^rd3	involves: BALB/cByJ * C57BL/6	MGI:3803151
cx4	Mrdq3^C57BL/6/Mrdq3^C57BL/6 Rd3^rd3/Rd3^rd3	involves: BALB/cByJ * C57BL/6	MGI:3803152
cx5	Mrdq4^C57BL/6/Mrdq4^C57BL/6 Rd3^rd3/Rd3^rd3	involves: BALB/cByJ * C57BL/6	MGI:3803153
cx6	Mrdq5^C57BL/6/Mrdq5^C57BL/6 Rd3^rd3/Rd3^rd3	involves: BALB/cByJ * C57BL/6	MGI:3803154

Allelic Composition	Rd3^rd3/Rd3^rd3
Genetic Background	RBF/DnJ-Rd3^rd3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

thin retina outer nuclear layer ( J:4367 )

• after 3 weeks, the outer nuclear layer is reduced

• however, mice have normal eye morphology prior to 3 weeks

abnormal retina photoreceptor layer morphology ( J:4367 )

• after 3 weeks, the photoreceptor layer is reduced

• however, mice have normal eye morphology prior to 3 weeks

absent retina rod cells ( J:4367 )

• at 4 weeks rods are no longer detected

retina photoreceptor degeneration ( J:4367 )

• by 8 weeks no photoreceptors are present

abnormal eye electrophysiology ( J:4367 )

• at week 4, the b-wave amplitude is 25% of that in wild-type mice

• by 6 weeks, a signal is barely detectable even with the brightest stimuli

nervous system

absent retina rod cells ( J:4367 )

• at 4 weeks rods are no longer detected

retina photoreceptor degeneration ( J:4367 )

• by 8 weeks no photoreceptors are present

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Leber congenital amaurosis 12		DOID:0110080	OMIM:610612	J:202634

Allelic Composition	Mrdq1^C57BL/6/Mrdq1^C57BL/6 Rd3^rd3/Rd3^rd3
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrdq1^C57BL/6 mutation (0 available); any Mrdq1 mutation (0 available)
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:136923 )

• resistance to retinal degeneration

Allelic Composition	Mrdq2^BALB/cByJ/Mrdq2^BALB/cByJ Rd3^rd3/Rd3^rd3
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrdq2^BALB/cByJ mutation (0 available); any Mrdq2 mutation (0 available)
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:136923 )

• resistance to retinal degeneration

Allelic Composition	Mrdq3^C57BL/6/Mrdq3^C57BL/6 Rd3^rd3/Rd3^rd3
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrdq3^C57BL/6 mutation (0 available); any Mrdq3 mutation (0 available)
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:136923 )

• resistance to retinal degeneration

Allelic Composition	Mrdq4^C57BL/6/Mrdq4^C57BL/6 Rd3^rd3/Rd3^rd3
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrdq4^C57BL/6 mutation (0 available); any Mrdq4 mutation (0 available)
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:136923 )

• resistance to retinal degeneration

Allelic Composition	Mrdq5^C57BL/6/Mrdq5^C57BL/6 Rd3^rd3/Rd3^rd3
Genetic Background	involves: BALB/cByJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrdq5^C57BL/6 mutation (0 available); any Mrdq5 mutation (0 available)
Rd3^rd3 mutation (4 available); any Rd3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina degeneration ( J:136923 )

• resistance to retinal degeneration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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