Phenotypes associated with this allele

• Allele Symbol: Ggt1^dwg
• Allele Name: dwarf grey
• Allele ID: MGI:1856850
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ggt1^dwg/Ggt1^dwg	(STOCK Pou1f1^dw x T(8;16)17H)F1	MGI:3026625
hm2	Ggt1^dwg/Ggt1^dwg	STOCK Ggt1^dwg/J	MGI:3764476

Genotype
MGI:3026625

hm1

• Allelic Composition: Ggt1^dwg/Ggt1^dwg
• Genetic Background: (STOCK Pou1f1^dw x T(8;16)17H)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:14281 )

• appear grey

growth/size/body

disproportionate dwarf ( J:14281 )

hematopoietic system

increased osteoclast cell number ( J:14281 )

• increased numbers of osteoclasts

decreased spleen red pulp amount ( J:14281 )

immune system

increased osteoclast cell number ( J:14281 )

• increased numbers of osteoclasts

decreased spleen red pulp amount ( J:14281 )

reproductive system

infertility ( J:14281 )

• mice are unable to breed

skeleton

increased osteoclast cell number ( J:14281 )

• increased numbers of osteoclasts

decreased bone mass ( J:14281 )

vision/eye

cataract ( J:14281 )

• obvious at 3-4 weeks of age

homeostasis/metabolism

decreased thyroxine level ( J:14281 )

• slightly reduced thyroxin levels

integument

diluted coat color ( J:14281 )

• appear grey

Genotype
MGI:3764476

hm2

• Allelic Composition: Ggt1^dwg/Ggt1^dwg
• Genetic Background: STOCK Ggt1^dwg/J

Small body size, grey coat color and cataracts of Ggt1^dwg/Ggt1^dwg mice (lower)

growth/size/body

decreased body size ( J:156192 )

skeleton

short femur ( J:156192 )

short tibia ( J:156192 )

small vertebrae ( J:156192 )

abnormal skeleton development ( J:156192 )

• retarded bone growth

abnormal long bone epiphyseal plate proliferative zone ( J:156192 )

• narrower tibial zone of proliferative chondrocytes

abnormal long bone hypertrophic chondrocyte zone ( J:156192 )

• decrease in the number of hypertrophic chondrocytes in the tibia

decreased long bone epiphyseal plate size ( J:156192 )

• decrease in the thickness of the tibial growth plate

limbs/digits/tail

short femur ( J:156192 )

short tibia ( J:156192 )