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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col1a1Mov13
Moloney leukemia virus 13
MGI:1856671
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Col1a1Mov13/Col1a1Mov13 C57BL/6-Col1a1Mov13 MGI:3620078
hm2
Col1a1Mov13/Col1a1Mov13 involves: C57BL/6 MGI:3608493
ht3
Col1a1Mov13/Col1a1+ C57BL/6-Col1a1Mov13 MGI:3620077
ht4
Col1a1Mov13/Col1a1+ involves: C57BL/6 MGI:3620112


Genotype
MGI:3620078
hm1
Allelic
Composition
Col1a1Mov13/Col1a1Mov13
Genetic
Background
C57BL/6-Col1a1Mov13
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1Mov13 mutation (1 available); any Col1a1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• bone development and extent of ossification is markedly reduced when prospective bone-forming regions (parts of the lower jaw or central portion of the limbs of E12.5-13.5 embryos) are transplanted under the kidney capsule of adult wild-type hosts or onto chorioallantoic membrane of 8 day chick embryos
• bone formation is initiated in two embryos that survive to E16, however bone development is retarded and does not progress to later stages of endochondrial ossification




Genotype
MGI:3608493
hm2
Allelic
Composition
Col1a1Mov13/Col1a1Mov13
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1Mov13 mutation (1 available); any Col1a1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygous embryos are degenerated and bloodless at E13 - E14 with none seen at E15

embryo
• embryos stop developing at E11.5 - E12




Genotype
MGI:3620077
ht3
Allelic
Composition
Col1a1Mov13/Col1a1+
Genetic
Background
C57BL/6-Col1a1Mov13
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1Mov13 mutation (1 available); any Col1a1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• between 6-8 weeks of age, many single, interspersed hairs turn white, indicating premature hair color change

integument
• between 6-8 weeks of age, many single, interspersed hairs turn white, indicating premature hair color change




Genotype
MGI:3620112
ht4
Allelic
Composition
Col1a1Mov13/Col1a1+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1Mov13 mutation (1 available); any Col1a1 mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• profound and progressive hearing loss with age
• profound and progressive hearing loss with age

skeleton
• modulus of elasticity of cortical bone is lower
• disorganized cortical bone, with bone cells not organized in a normal osteonal pattern and diorganization of collagen within the cortex
• exhibit a significant difference in the load deformation response of bones at failure, indicating brittle and fragile bones, however stiffness is normal
• modulus of elasticity of cortical bone is lower

integument
• dermis contains unusually thin collagen fibers and collagen content in the dermis is reduced by about 50%

Mouse Models of Human Disease
OMIM ID Ref(s)
Osteogenesis Imperfecta, Type I; OI1 166200 J:107045





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory