mortality/aging

partial postnatal lethality ( J:4060 )

• homozygotes represent about 10.6% of pups from matings of heterozygotes

growth/size

decreased body weight ( J:4060 )

• about half normal at 3 weeks of age

immune system

absent T cells ( J:4060 )

• absence of mature T-cells although precursors present in bone marrow

abnormal thymus development ( J:4060 )

• two rudimentary lobules of thymus in apical mediastinum lack a developed stroma and lymphoid infiltration

• almost completely replaced with adipose and mucoid cells by 7.5 weeks of age

athymia ( J:4060 , J:29022 )

• at 11 days (J:4060)

hematopoietic system