Mouse Genome Informatics
hm1
    Glra1spd/Glra1spd
B6C3Fe a/a-Glra1spd/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• males appear unable to breed (J:9027)
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type (J:107699)
• in mutants, the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type

behavior/neurological
• exhibit difficulty in regaining an upright posture when turned on their sides
• response improved in mice receiving IP injections of aminooxyacetic acid, 15 micrograms/gm body weight
• tend to clasp their hind feet when picked up by the tail and spun
• at rest, in a quiet cage, appear normal but are hyperexcitable and shake rapidly when disturbed
• exhibit a rapid tremor when picked up by the tail, however show no differences in the levels of the major CNS and PNS myelin proteins of lipids
• stiff posture
• mimics sublethal strychnine intoxication
• walk slowly and on their toes

muscle
• mimics sublethal strychnine intoxication


Mouse Genome Informatics
hm2
    Glra1spd/Glra1spd
involves: A/HeJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• exhibit increased startle responses to acoustic stimuli of different intensities compared to wild-type
• homozygotes are more responsive than Glrbspa homozygotes at the lowest stimulus intensities

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperekplexia, Hereditary 1; HKPX1 149400 J:33924


Mouse Genome Informatics
ht3
    Glra1spd/Glra1+
B6C3Fe a/a-Glra1spd/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type (J:107699)
• in mutants, the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type