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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glra1spd
spasmodic
MGI:1856362
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Glra1spd/Glra1spd B6C3Fe a/a-Glra1spd/J MGI:3581145
hm2
Glra1spd/Glra1spd involves: A/HeJ MGI:3695040
ht3
Glra1spd/Glra1+ B6C3Fe a/a-Glra1spd/J MGI:3622188


Genotype
MGI:3581145
hm1
Allelic
Composition
Glra1spd/Glra1spd
Genetic
Background
B6C3Fe a/a-Glra1spd/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1spd mutation (1 available); any Glra1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type
• males appear unable to breed
• in mutants, the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type

behavior/neurological
• exhibit difficulty in regaining an upright posture when turned on their sides
• response improved in mice receiving IP injections of aminooxyacetic acid, 15 micrograms/gm body weight
• tend to clasp their hind feet when picked up by the tail and spun
• at rest, in a quiet cage, appear normal but are hyperexcitable and shake rapidly when disturbed
• exhibit a rapid tremor when picked up by the tail, however show no differences in the levels of the major CNS and PNS myelin proteins of lipids
• stiff posture
• mimics sublethal strychnine intoxication
• walk slowly and on their toes

muscle
• mimics sublethal strychnine intoxication

cellular
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type




Genotype
MGI:3695040
hm2
Allelic
Composition
Glra1spd/Glra1spd
Genetic
Background
involves: A/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1spd mutation (1 available); any Glra1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exhibit increased startle responses to acoustic stimuli of different intensities compared to wild-type
• homozygotes are more responsive than Glrbspa homozygotes at the lowest stimulus intensities

Mouse Models of Human Disease
OMIM ID Ref(s)
Hyperekplexia, Hereditary 1; HKPX1 149400 J:33924




Genotype
MGI:3622188
ht3
Allelic
Composition
Glra1spd/Glra1+
Genetic
Background
B6C3Fe a/a-Glra1spd/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra1spd mutation (1 available); any Glra1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type
• in mutants, the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type

cellular
• the zona pellucida-initiated acrosome reaction is significantly decreased compared to wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory