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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Faslpr-cg
lymphoproliferation complementing gld
MGI:1856335
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Faslpr-cg/Faslpr-cg CBA/KlJms-Faslpr-cg/J MGI:2449985


Genotype
MGI:2449985
hm1
Allelic
Composition
Faslpr-cg/Faslpr-cg
Genetic
Background
CBA/KlJms-Faslpr-cg/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr-cg mutation (3 available); any Fas mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• earliest deaths at 19 and 29 weeks of age
• survival rate at 1 year is 61.1% in males and 46.2% in females

immune system
• anomalous differentiation of T cells, with anomalous expression of surface antigens
• five times higher than in controls (J:81770)
• two times higher than in controls (J:81770)
• palpable by 3 months of age
• spleens larger in females than males
• spleen weights increase up to 6 months of age and remain at a plateau thereafter
• enlargement of the superficial lymph nodes starts at about 2.5 months of age, with cervical preceding inguinal lymph nodes (J:24805)
• superficial lymph nodes are more than 5 and 15 times heavier than controls at 3 and 5 months of age, respectively (J:24805)
• mesenteric lymph nodes are normal in size (J:24805)
• lymphocyte infiltration in liver, lungs, spleen, and kidneys (J:24805)
• elevated levels of autoantibodies to nuclear antigens including anti-DNA

hematopoietic system
• anomalous differentiation of T cells, with anomalous expression of surface antigens
• palpable by 3 months of age
• spleens larger in females than males
• spleen weights increase up to 6 months of age and remain at a plateau thereafter
• five times higher than in controls (J:81770)
• two times higher than in controls (J:81770)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autoimmune Lymphoproliferative Syndrome; ALPS 601859 J:24805 , J:81770





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory