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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mcoln3Va
varitint waddler
MGI:1856230
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mcoln3Va/Mcoln3Va involves: C57BL * C57BR MGI:3696790
hm2
Mcoln3Va/Mcoln3Va mixed MGI:3696961
ht3
Mcoln3Va/Mcoln3+ involves: C57BL * C57BR MGI:3696789
ht4
Mcoln3Va/Mcoln3+ mixed MGI:3696960
ht5
Mcoln3Va/Mcoln3Va-J Not Specified MGI:3697410


Genotype
MGI:3696790
hm1
Allelic
Composition
Mcoln3Va/Mcoln3Va
Genetic
Background
involves: C57BL * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mortality is very high in homozygotes, and very few of the survivors are fertile

hearing/vestibular/ear

behavior/neurological
• in reaction to sudden jarring
• Homozygotes show more intense behavioral abnormalities than heterozygotes
• usually in motion when not asleep, nodding and tossing their heads
• Homozygotes show more intense behavioral abnormalities than heterozygotes
• waddling "duck like" walk
• Homozygotes show more intense behavioral abnormalities than heterozygotes
• Homozygotes show more intense behavioral abnormalities than heterozygotes
• mixed circling habits are present as early as 14 days after birth
• Homozygotes show more intense behavioral abnormalities than heterozygotes
• neglect their young and trample pups
• a convulsive stiffening of the body in reaction to sudden jarring
• Homozygotes show more intense behavioral abnormalities than heterozygotes

nervous system
• a convulsive stiffening of the body in reaction to sudden jarring
• Homozygotes show more intense behavioral abnormalities than heterozygotes

pigmentation
• their coats are white, except for small patches of unaltered color near the ears and base of the tail

reproductive system
• very few of the survivors are fertile

integument
• their coats are white, except for small patches of unaltered color near the ears and base of the tail




Genotype
MGI:3696961
hm2
Allelic
Composition
Mcoln3Va/Mcoln3Va
Genetic
Background
mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mortality is very high in homozygotes

behavior/neurological
• often homozygous do not right themselves

hearing/vestibular/ear
• at 35 days the hair cells are gone
• the cells of Deiter are still present and not dedifferentiated
• becomes distinctly abnormal at the age of 17 days
• nuclei becomes rounded and later lose their cytoplasmic processes
• more severely affected than heterozygous mice
• loses all contact with the organ of Corti by 7 days
• remain detached from the organ of Corti and later shrivels up
• more severely affected than heterozygous mice
• staring 4 days of age
• the tectorial membrane in mutant mice forms a big bulge instead of forming a thin strand of the outer marginal zone
• more severely affected than heterozygous mice
• at age of 25 days the hairs have mostly disappeared
• the gelatinous cupula remains
• more severely affected than heterozygous mice

nervous system
• at 35 days the hair cells are gone
• the cells of Deiter are still present and not dedifferentiated
• a change in the shape of the cells and their nuclei are seen starting at the age of 6 days
• more severely affected than heterozygous mice
• a reduction in cell size and density by 9 days
• destruction of nerve cells through life
• more severely affected than heterozygous mice and degeneration is quicker
• the average cell size in the vestibular ganglion is reduced
• more severely affected than heterozygous mice




Genotype
MGI:3696789
ht3
Allelic
Composition
Mcoln3Va/Mcoln3+
Genetic
Background
involves: C57BL * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• at 2 weeks of age heterozygotes only return positive waveforms to an 8 kHz stimulus at 95 dB and by 3 weeks of age there is no response to click or 32 kHz stimuli

behavior/neurological
• in reaction to sudden jarring
• usually in motion when not asleep, nodding and tossing their heads
• waddling "duck like" walk
• choreic head movements
• mixed circling habits are present as early as 14 days after birth
• neglect their young and trample pups
• a convulsive stiffening of the body in reaction ot sudden jarring

nervous system
• a convulsive stiffening of the body in reaction ot sudden jarring

pigmentation
• with patches of normal-colored, diluted, and white fur
• coat color is more dilute and mottled than in Va-J heterozygotes, with an entirely white ventrum and a large white spot on the forehead

reproductive system
• some of the heterozygous mice, especially the males are sterile

integument
• with patches of normal-colored, diluted, and white fur
• coat color is more dilute and mottled than in Va-J heterozygotes, with an entirely white ventrum and a large white spot on the forehead




Genotype
MGI:3696960
ht4
Allelic
Composition
Mcoln3Va/Mcoln3+
Genetic
Background
mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• a marked inability to negotiate a narrow bridge at two or three days before their eyes open
• elderly heterozygous mice over 10 months old cannot swim

hearing/vestibular/ear
• unequal size of the hair cells by 11 day
• some of hair cells disappear entirely by the 17th day
• the others are drastically reduced
• becomes distinctly abnormal at the age of 17 days
• nuclei becomes rounded and later lose their cytoplasmic processes
• loses all contact with the organ of Corti by 7 days
• remain detached from the organ of Corti and later shrivels up
• staring 4 days of age
• the tectorial membrane in mutant mice forms a big bulge instead of forming a thin strand of the outer marginal zone
• at age of 25 days the hairs have mostly disappeared
• the gelatinous cupula remains

nervous system
• unequal size of the hair cells by 11 day
• some of hair cells disappear entirely by the 17th day
• the others are drastically reduced
• a change in the shape of the cells and their nuclei are seen starting at the age of 6 days
• a reduction in cell size and density by 9 days
• destruction of nerve cells through life
• the average cell size in the vestibular ganglion is reduced




Genotype
MGI:3697410
ht5
Allelic
Composition
Mcoln3Va/Mcoln3Va-J
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (20 available)
Mcoln3Va-J mutation (4 available); any Mcoln3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 12 compound heterozygotes were produced in 231 progeny from a Va/+ and VaJ/+ cross (over 50 expected) and 4 of these died young

pigmentation
• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J

behavior/neurological
• abnormal behavior like Mcoln3Va/Mcoln3+
• circling is described as vigorous

growth/size/body
• somewhat smaller than the VaJ homozygous mice

hearing/vestibular/ear

reproductive system
• only one male bred at 10 months of age

integument
• mostly white with patches of dilute color like Mcoln3Va-J/Mcoln3Va-J





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory