• mice die either before and after implantation with the exact timing of lethality unknown

• females are poor breeders (J:8534)

• however, some embryo death may be associated with prenatal lethality (J:8534)

• mice often develop coloboma visible by day 14

• one or both ears

• one or both ears

• at 2.5 weeks mice are smaller than normal

• one or both ears

• one or both ears

• some mice may have a white belly spot or streak

• some mice may have a white belly spot or streak

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

• facial development is retarded compared to wild-type and Pax6^Sey homozygotes

• while small bleds are present in the area occupied by the eye they contain no brain involvement

• at E13.5, mice are smaller than wild-type and Pax6^sey homozygotes

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

• at E13.5, mice are smaller than wild-type and Pax6^sey homozygotes