Mouse Genome Informatics
hm1
    Pax6Sey-H/Pax6Sey-H
involves: 101/H * C3H/HeH
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die either before and after implantation with the exact timing of lethality unknown


Mouse Genome Informatics
ht2
    Pax6Sey-H/Pax6+
involves: 101/H * C3H/HeH
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
reproductive system
• females are poor breeders (J:8534)
• however, some embryo death may be associated with prenatal lethality (J:8534)

vision/eye
• mice often develop coloboma visible by day 14

hearing/vestibular/ear
• one or both ears
• one or both ears

growth/size/body
• one or both ears
• one or both ears
• at 2.5 weeks mice are smaller than normal

craniofacial
• one or both ears
• one or both ears

pigmentation
• some mice may have a white belly spot or streak

integument
• some mice may have a white belly spot or streak


Mouse Genome Informatics
ht3
    Pax6Sey/Pax6Sey-H
involves: 101/H * C3H/HeH * C57BL/10
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
craniofacial
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side
• facial development is retarded compared to wild-type and Pax6Sey homozygotes

vision/eye
• while small bleds are present in the area occupied by the eye they contain no brain involvement

embryogenesis
• at E13.5, mice are smaller than wild-type and Pax6sey homozygotes

skeleton
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

digestive/alimentary system
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

growth/size/body
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side
• at E13.5, mice are smaller than wild-type and Pax6sey homozygotes