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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pax6Sey-H
small eye, Harwell
MGI:1856156
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pax6Sey-H/Pax6Sey-H involves: 101/H * C3H/HeH MGI:2175205
ht2
Pax6Sey-H/Pax6+ involves: 101/H * C3H/HeH MGI:2175206
ht3
Pax6Sey/Pax6Sey-H involves: 101/H * C3H/HeH * C57BL/10 MGI:3767472


Genotype
MGI:2175205
hm1
Allelic
Composition
Pax6Sey-H/Pax6Sey-H
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey-H mutation (2 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die either before and after implantation with the exact timing of lethality unknown




Genotype
MGI:2175206
ht2
Allelic
Composition
Pax6Sey-H/Pax6+
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey-H mutation (2 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• females are poor breeders
• however, some embryo death may be associated with prenatal lethality

vision/eye
• mice often develop coloboma visible by day 14

hearing/vestibular/ear
• one or both ears
• one or both ears

growth/size/body
• one or both ears
• one or both ears
• at 2.5 weeks mice are smaller than normal

craniofacial
• one or both ears
• one or both ears

pigmentation
• some mice may have a white belly spot or streak

integument
• some mice may have a white belly spot or streak




Genotype
MGI:3767472
ht3
Allelic
Composition
Pax6Sey/Pax6Sey-H
Genetic
Background
involves: 101/H * C3H/HeH * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6Sey mutation (3 available); any Pax6 mutation (54 available)
Pax6Sey-H mutation (2 available); any Pax6 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side
• facial development is retarded compared to wild-type and Pax6Sey homozygotes

vision/eye
• while small bleds are present in the area occupied by the eye they contain no brain involvement

embryo
• at E13.5, mice are smaller than wild-type and Pax6sey homozygotes

skeleton
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

digestive/alimentary system
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side

growth/size/body
• at E13.5, the maxillae are not fused and there is only a small bilobed protrusion in the frontonasal position that in some mice may fuse on one side
• at E13.5, mice are smaller than wild-type and Pax6sey homozygotes





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory