Mouse Genome Informatics
hm1
    Tyrc-h/Tyrc-h
B6.Cg-Tyrc-h/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

integument
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

vision/eye
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

Mouse Models of Human Disease
OMIM IDRef(s)
Albinism, Oculocutaneous, Type IB; OCA1B 606952 J:178454


Mouse Genome Informatics
hm2
    Tyrc-h/Tyrc-h
involves: AKR/J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
• pink eye color of the new born darkens to ruby-colored by weaning

vision/eye
• pink eye color of the new born darkens to ruby-colored by weaning

integument
• at one week of age affected mice are slightly darker than albinos, particularly on tail
• the body coat color may range from unifrom to slightly lighter dorsal and ventral across the shoulders, darker toward the tail where a very dark ring of body fur develops adjacent to the tail
• at first molt the nose, ears, tail, and scrotum but not the feet become considerably darker; the rest of the body becomes lighter
• dark hair on the nose extends back to the anterior border of the eyes
• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail


Mouse Genome Informatics
hm3
    Tyrc-h/Tyrc-h
involves: C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice

integument
• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice


Mouse Genome Informatics
ht4
    Tyrc-h/Tyrc
involves: AKR/J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• coats of juvenile mice are very pale buff
• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan

vision/eye
• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan

integument
• although indistinguishable from albino at birth coat color is intermediate between albino and homozygous himalayan at about one week of age
• with the first molt extremities darken but not as dark as seen in the homozygote
• coats of juvenile mice are very pale buff


Mouse Genome Informatics
ht5
    Tyrc-a/Tyrc-h
involves: C3H/HeJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes

integument
• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes


Mouse Genome Informatics
ht6
    Tyrc-h/Tyrc-25H
STOCK Tyrc-h/Tyrc-25H
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
pigmentation
• coat color is lighter than homozygous chinchilla but not albino

integument
• coat color is lighter than homozygous chinchilla but not albino