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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tyrc-h
himalayan
MGI:1855979
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tyrc-h/Tyrc-h B6.Cg-Tyrc-h/J MGI:5316479
hm2
Tyrc-h/Tyrc-h involves: AKR/J * DBA/2J MGI:4366352
hm3
Tyrc-h/Tyrc-h involves: C57BL/6 MGI:3794761
ht4
Tyrc-h/Tyrc involves: AKR/J * DBA/2J MGI:4366353
ht5
Tyrc-a/Tyrc-h involves: C3H/HeJ MGI:4360479
ht6
Tyrc-h/Tyrc-25H STOCK Tyrc-h/Tyrc-25H MGI:3691858


Genotype
MGI:5316479
hm1
Allelic
Composition
Tyrc-h/Tyrc-h
Genetic
Background
B6.Cg-Tyrc-h/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

integument
• the first coat is a uniform light tan
• at the first molt, the body hair becomes lighter, and the ears, nose, tail and scrotum become dark
• mutants treated with nitisinone show increased pigmentation in areas of new hair growth

vision/eye
• mutants exhibit iris transillumination that is not observed in wild-type mice
• mutants treated with nitisinone show increased pigmentation in the irides
• eyes are minimally pigmented and appear red

Mouse Models of Human Disease
OMIM ID Ref(s)
Albinism, Oculocutaneous, Type IB; OCA1B 606952 J:178454




Genotype
MGI:4366352
hm2
Allelic
Composition
Tyrc-h/Tyrc-h
Genetic
Background
involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail
• pink eye color of the new born darkens to ruby-colored by weaning

vision/eye
• pink eye color of the new born darkens to ruby-colored by weaning

integument
• at one week of age affected mice are slightly darker than albinos, particularly on tail
• the body coat color may range from unifrom to slightly lighter dorsal and ventral across the shoulders, darker toward the tail where a very dark ring of body fur develops adjacent to the tail
• at first molt the nose, ears, tail, and scrotum but not the feet become considerably darker; the rest of the body becomes lighter
• dark hair on the nose extends back to the anterior border of the eyes
• the fully grown juvenile coat is pale tan with little evidence of darkening of extremities except the tail




Genotype
MGI:3794761
hm3
Allelic
Composition
Tyrc-h/Tyrc-h
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice

integument
• mice have slight pigmentation of the coat
• the amount of melanin found in anagen hairbulbs is reduced by more than 10-fold compared to wild-type mice




Genotype
MGI:4366353
ht4
Allelic
Composition
Tyrc-h/Tyrc
Genetic
Background
involves: AKR/J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation (140 available); any Tyr mutation (365 available)
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• coats of juvenile mice are very pale buff
• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan

vision/eye
• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan

integument
• although indistinguishable from albino at birth coat color is intermediate between albino and homozygous himalayan at about one week of age
• with the first molt extremities darken but not as dark as seen in the homozygote
• coats of juvenile mice are very pale buff




Genotype
MGI:4360479
ht5
Allelic
Composition
Tyrc-a/Tyrc-h
Genetic
Background
involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-a mutation (2 available); any Tyr mutation (365 available)
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes

integument
• the coat is lighter than mice that are homozygous Tyrc-h but indistinguishable from acromelanic homozygotes




Genotype
MGI:3691858
ht6
Allelic
Composition
Tyrc-h/Tyrc-25H
Genetic
Background
STOCK Tyrc-h/Tyrc-25H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc-25H mutation (0 available); any Tyr mutation (365 available)
Tyrc-h mutation (2 available); any Tyr mutation (365 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• coat color is lighter than homozygous chinchilla but not albino

integument
• coat color is lighter than homozygous chinchilla but not albino





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory